PERIPHERAL NERVE ULTRASOUND IN AMYOTROPHIC LATERAL SCLEROSIS PHENOTYPES
PERIPHERAL NERVE ULTRASOUND IN AMYOTROPHIC LATERAL SCLEROSIS PHENOTYPES
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DOI：
10.1002/mus.24431
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发表时间：
2015-05-01
期刊：
影响因子：
3.4
通讯作者：
Vielhaber, Stefan
中科院分区：
文献类型：
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作者：
Schreiber, Stefanie;Abdulla, Susanne;Vielhaber, Stefan
在这项研究中，我们试图确定不同亚型肌萎缩性侧索硬化症（ALS）患者周围神经的横截面积（CSA）。方法：78例ALS患者行尺正中神经超声检查[经典，n=21；上运动神经元显性（UMND）， n=14；下运动神经元显性（LMND）， n=20；球,n = 15;原发性侧索硬化（PLS）， n=8]和18名匹配的健康对照。结果：与对照组相比，除了PLS外，所有疾病组的ALS患者尺骨CSA（前臂/手腕水平）远端明显降低，正中神经CSA（前臂/手腕水平）在对照组和ALS之间没有差异。结论：尺神经超声在ALS亚组中显示远端CSA值有显著差异，提示其作为LMN受累的标志具有一定的价值。它的潜力在UMND和PLS组中尤其明显，这两组在临床上很难分离，但它们的准确分离具有重要的预后意义。中国生物医学工程学报，2015
Introduction: In this study we sought to determine the cross-sectional area (CSA) of peripheral nerves in patients with distinct subtypes of amyotrophic lateral sclerosis (ALS). Methods: Ulnar and median nerve ultrasound was performed in 78 ALS patients [classic, n=21; upper motor neuron dominant (UMND), n=14; lower motor neuron dominant (LMND), n=20; bulbar, n=15; primary lateral sclerosis (PLS), n=8] and 18 matched healthy controls. Results: Compared with controls, ALS patients had significant, distally pronounced reductions of ulnar CSA (forearm/wrist level) across all disease groups, except for PLS. Median nerve CSA (forearm/wrist level) did not differ between controls and ALS. Conclusion: Ulnar nerve ultrasound in ALS subgroups revealed significant differences in distal CSA values, which suggests it has value as a marker of LMN involvement. Its potential was particularly evident in the UMND and PLS groups, which can be hard to separate clinically, yet their accurate separation has major prognostic implications. Muscle Nerve51:669-675, 2015