Active retinal tracker for clinical optical coherence tomography systems
Active retinal tracker for clinical optical coherence tomography systems
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DOI：
10.1117/1.1896967
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发表时间：
2005-03-01
影响因子：
3.5
通讯作者：
Schuman, JS
中科院分区：
文献类型：
--
作者：
Hammer, DX;Ferguson, RD;Schuman, JS
一个积极的，基于硬件的视网膜跟踪器集成了临床光学相干断层扫描（OCT）系统，以调查的影响，稳定的高分辨率视网膜切片的收购。原型视网膜跟踪器锁定到共同的眼底特征上，通过特征反射率的变化检测横向眼睛运动，并利用由反馈控制回路驱动的反射镜将OCT诊断光束定位到视网膜上的固定坐标。该系统在具有正常眼睛和青光眼眼睛的受试者的完整临床方案中进行测试。开发了实验分析软件，用于将多幅Funcus图像和OCT图像进行共对齐和共添加，并提取图像中结构位置的定量信息。跟踪是高度准确和可重复的所有，但一个主题，从而能够扫描相同的视网膜位置连续很长一段时间。结果显示，97%的联合OCT扫描的质量改善，视盘杯边缘位置的方差减少到小于1个像素（< 60 μ m）。该跟踪系统可以很容易地配置用于研究先进的图像模态的超高分辨率OCT系统。例如，跟踪将实现视网膜的非常高密度的3-D扫描，即使对于新的高速系统，这也容易受到眼睛运动伪影的影响。(c)2005年光学仪器工程师学会。
An active, hardware-based retinal tracker is integrated with a clinical optical coherence tomography (OCT) system to investigate the effects of stabilization on acquisition of high-resolution retinal sections. The prototype retinal tracker locks onto common fundus features, detects transverse eye motion via changes in feature reflectance, and positions the OCT diagnostic beam to fixed coordinates on the retina with mirrors driven by a feedback control loop. The system is tested in a full clinical protocol on subjects with normal and glaucomatous eyes. Experimental analysis software is developed to coalign and coadd multiple funclus and OCT images and to extract quantitative information on the location of structures in the images. Tracking is highly accurate and reproducible on all but one subject, resulting in the ability to scan the same retinal location continually over long periods of time. The results show qualitative improvement in 97% of coadded OCT scans and a reduction in the variance of the position of the optic disc cup edge to less than 1 pixel (< 60 mu m). The tracking system can be easily configured for use in research on ultra-high-resolution OCT systems for advanced image modalities. For example, tracking will enable very high density 3-D scans of the retina, which are susceptible to eye motion artifacts even for new high-speed systems. (c) 2005 Society of Photo-Optical Instrumentation Engineers.