Calcium Buffering in the Heart in Health and Disease
Calcium Buffering in the Heart in Health and Disease
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DOI：
10.1161/circulationaha.118.039329
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发表时间：
2019-05-14
期刊：
影响因子：
37.8
通讯作者：
Eisner, David A.
中科院分区：
文献类型：
--
作者：
Smith, Godfrey L.;Eisner, David A.
细胞内钙离子浓度的变化调节心肌细胞功能的多个方面。心肌细胞内约99%的胞浆钙与缓冲液结合，其性质对钙信号转导有重要影响。本文考虑缓冲区的基本属性和身份，以及如何测量它们。它综述了缓冲对收缩期钙瞬变的影响及其生理变化，以及在心力衰竭和房性和室性心律失常中的作用。结论是，这种强缓冲的后果可能比目前所认识的更重要，需要更充分的了解才能正确理解心脏的钙循环和收缩能力。
Changes of intracellular Ca2+ concentration regulate many aspects of cardiac myocyte function. About 99% of the cytoplasmic calcium in cardiac myocytes is bound to buffers, and their properties will therefore have a major influence on Ca2+ signaling. This article considers the fundamental properties and identities of the buffers and how to measure them. It reviews the effects of buffering on the systolic Ca2+ transient and how this may change physiologically, and in heart failure and both atrial and ventricular arrhythmias, as well. It is concluded that the consequences of this strong buffering may be more significant than currently appreciated, and a fuller understanding is needed for proper understanding of cardiac calcium cycling and contractility.