Effects of the atypical antipsychotic olanzapine on reproductive function and weight gain in female rats
Effects of the atypical antipsychotic olanzapine on reproductive function and weight gain in female rats
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DOI：
10.1177/0269881104042613
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发表时间：
2004-06-01
影响因子：
4.1
通讯作者：
Neill, JC
中科院分区：
文献类型：
--
作者：
Fell, MJ;Marshall, KM;Neill, JC
性功能障碍是抗精神病药物治疗的一个主要副作用，尽管知之甚少。我们最近发现，亚慢性使用利培酮和氟哌啶醇治疗的雌性大鼠的生殖功能和体重增加明显中断。本研究的目的是进一步研究用奥氮平治疗的雌性大鼠的生殖功能障碍和体重增加之间的潜在关系。研究了奥氮平对群养成年雌性白领大鼠体重增加、食物和水摄入量、腹内脂肪、发情周期和子宫重量的影响。奥氮平(0.5-4.0 mg/kg ip)每天给药一次，连续21天，测量体重、摄食量和饮水量，阴道灌洗液组织学检查以确定发情周期的阶段。第22天处死动物，测量腹内脂肪、子宫湿重和子宫干重。奥氮平导致体重显著增加，同时食物和水摄入量增加，腹内脂肪增加，但对发情周期、子宫湿重和干重或血浆催乳素水平没有影响。这些结果证实了奥氮平能够诱导不受限制的正常饮食的雌性大鼠体重增加，并伴随着食物和水摄入量的增加以及腹内脂肪的增加。奥氮平的这些作用是在没有任何明显的生殖功能损害的情况下产生的，与之前利培酮和氟哌啶醇治疗的大鼠发情和子宫萎缩的实质性中断形成对比。
Sexual dysfunction is a major, although poorly understood, side-effect of treatment with antipsychotic drugs. We have recently show marked disruption of reproductive function and weight gain in female rats treated subchronically with risperidone and haloperidol. The aim of the present study was to examine further the potential relationship between reproductive dysfunction and weight gain in female rats treated with olanzapine. The effects of olanzapine on weight gain, food and water intake, intra-abdominal fat, the oestrous cycle and uterine weight were assessed in group-housed adult female hooded-Lister rats. Olanzapine (0.5-4.0 mg/kg i.p.) or vehicle was administered once daily for 21 days and body weight, food and water intake measured, with histological examination of vaginal lavage to determine the stage of the oestrous cycle. On day 22, animals were sacrificed and intra-abdominal fat, wet and dry uterine weights measured. Olanzapine induced significant weight gain with concomitant increases in food and water intake and intra-abdominal fat without an effect on the oestrous cycle, wet and dry uterine weights or plasma prolactin levels. These results confirm the ability of olanzapine to induce weight gain in female rats on unrestricted normal diet with a concomitant increase in food and water intake and increased intra-abdominal fat. These effects of olanzapine were produced in the absence of any apparent impairment in reproductive function, in contrast to the substantial disruption of oestrous and uterine atrophy previously shown in rats treated with risperidone and haloperidol.