Behavior of bone marrow-derived cells following in vivo transplantation: differentiation into stromal cells with roles in organ maintenance.
Behavior of bone marrow-derived cells following in vivo transplantation: differentiation into stromal cells with roles in organ maintenance.
复制标题
体内移植后骨髓来源细胞的行为：分化为在器官维持中发挥作用的基质细胞。
DOI：
10.1016/j.ajpath.2012.12.034
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发表时间：
2013
期刊：
影响因子：
6
通讯作者：
Fukushima A.
中科院分区：
文献类型：
--
作者：
Taguchi O;Tsujimura K;Kontani K;Harada Y;Nomura S;Ikeda H;Morita A;Sugiura H;Hayashi N;Yatabe Y;Seto M;Tatematsu M;Takahashi T;Fukushima A.
将绿色荧光蛋白阳性（GFP+）骨髓（BM）细胞注射到致死性照射的野生型小鼠中后，受体小鼠[BM移植（BMT）小鼠]的器官再生;然而，盲肠或脾脏（仅）的照射阻断了它们的再生，注射的BM细胞丢失。这些结果表明，供体细胞首先进入骨髓，然后迁移到外周器官。上皮结构和功能的维持是由基质细胞和上皮细胞之间的相互作用控制的;只有当基质功能正常时，器官才稳定。在BMT小鼠中，肠GFP+基质细胞再生相当迅速，尽管即使在BMT后几周或几个月，在肠上皮中也很少观察到GFP+细胞，这表明BM衍生的基质细胞在上皮更新中起关键作用，并且对于维持器官结构和功能至关重要。外周中的BM来源的细胞具有返回BM然后迁移到各种器官以成为驻留细胞的特殊钥匙。
After injection of green fluorescent protein–positive (GFP+) bone marrow (BM) cells into lethally irradiated wild-type mice, the organs of the recipient mice [BM transplantation (BMT) mice] were regenerated; however, irradiation of the cecum or spleen (only) blocked their regeneration with loss of injected BM cells. These results suggest that the donor cells first enter the BM and then migrate to the peripheral organs. The maintenance of epithelial structure and function is controlled by interactions between stromal cells and the epithelia; the organ is stable only if the stroma is functioning normally. In BMT mice, intestinal GFP+stromal cells were regenerated fairly rapidly although GFP+cells were observed only rarely in the intestinal epithelium even if it passes several weeks or months post BMT, indicating that BM-derived stromal cells play a pivotal role in epithelial renewal and are crucial for maintaining organ structure and function. BM-derived cells in the periphery possess a special key to return to the BM and then to migrate to various organs to become resident cells.