Mitochondrial Dysfunction in Neurodegenerative Diseases
Mitochondrial Dysfunction in Neurodegenerative Diseases
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DOI：
10.1124/jpet.112.192138
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发表时间：
2012-09-01
影响因子：
3.5
通讯作者：
Beal, M. Flint
中科院分区：
文献类型：
--
作者：
Johri, Ashu;Beal, M. Flint
神经退行性疾病是神经系统的一大批致残性疾病，其特征是神经元亚型的相对选择性死亡。在大多数情况下，有很多证据表明线粒体功能受损是这些疾病的病因。最近，有证据表明神经退行性疾病（如帕金森氏病，亨廷顿氏病，肌萎缩性的侧面硬化症和阿尔茨海默氏病）等神经退行性疾病的线粒体动力学（形状，大小，裂变，分布，运动等）。在这里，我们简要概述了近年来的主要发现，强调了健康线粒体对健康神经元的重要性。
Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, movement etc.) in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here, we provide a concise overview of the major findings in recent years highlighting the importance of healthy mitochondria for a healthy neuron.