Clinical patterns of metastasis
Clinical patterns of metastasis
复制标题
转移的临床模式
DOI：
10.1007/s10555-006-8502-8
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发表时间：
2006-06-01
影响因子：
9.2
通讯作者：
Kitajima, M.
中科院分区：
文献类型：
--
作者：
Leong, Stanley P. L.;Cady, Blake;Kitajima, M.
在人类实体癌中，淋巴结状态是临床结果最重要的指标。前哨淋巴结概念和技术的最新发展导致了检查前哨淋巴结微转移以及淋巴血管系统在促进癌症转移中的作用的更精确的方法。针对不同类型的实体癌描述了不同的转移模式。除了乳头状癌和肉瘤之外，压倒性的证据表明，在大多数病例中，实体癌从原发部位有序进展至区域淋巴结或前哨淋巴结，随后扩散至全身部位。癌症通过淋巴血管系统转移的基本机制构成了合理治疗癌症的基础。除了转移的临床模式之外，还必须了解转移的生物学，并根据其分子特征来表征可能由异质克隆引起的转移模式。
In human solid cancer, lymph node status is the most important indicator for clinical outcome. Recent developments in the sentinel lymph node concept and technology have resulted in a more precise way of examining micrometastasis in the sentinel lymph node and the role of lymphovascular system in the facilitation of cancer metastasis.Different patens of metastasis are described with respect to different types of solid cancer. Expect perhaps for papillary carcinoma and sarcoma, the overwhelming evidence is that solid cancer progresses in an orderly progression from the primary site to the regional lymph node or the sentinel lymph node in the majority of cases with subsequent dissemination to the systemic sites. The basic mechanisms of cancer metastasis through the lymphovascular system form the basis of rational therapy against cancer. Beyond the clinical patterns of metastasis, it is imperative to understand the biology of metastasis and to characterize patterns of metastasis perhaps due to heterogeneous clones based on their molecular signatures.