Variation in the prevalence of gastric cancer in Peru
Variation in the prevalence of gastric cancer in Peru
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DOI：
10.1002/ijc.23420
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发表时间：
2008-07-15
影响因子：
6.4
通讯作者：
Ramirez-Ramos, Alberto
中科院分区：
文献类型：
--
作者：
Mendoza, Daniel;Herrera, Phabiola;Ramirez-Ramos, Alberto
大多数胃癌病例发生在非工业化国家，但关于这些国家这种疾病的流行病学信息很少。我们的研究调查了过去20年里秘鲁利马的胃癌患病率是否有变化。受试者年龄大于29岁。他们在利马3家社会经济状况不同的医疗机构接受了食管胃内镜检查：一家县医院（7168名受试者），一家秘鲁-日本诊所（14794名受试者）和一家私立医院（4893名受试者）。采用出生队列胃癌患病率。计算回归模型来预测未来胃癌的患病率。研究发现，秘鲁低、中、高社会经济群体的出生队列胃癌患病率分别从22.7%降至2% (p < 0.001)，从12%降至0.5% (p < 0.001)，从6.5%降至0.1% （p < 0.001）。在低、中、高社会经济地位人群中，肠化生发生率分别从44.3%降至12.5% (p < 0.001)，从28.4%降至5% (p < 0.001)，从19.4%降至2.2% （p < 0.001）。这些趋势可能会持续几十年。然而，在59岁以上的低社会经济地位人群中，胃癌的患病率仍然很高。结论是，秘鲁的胃癌发病率正在下降，与工业化国家目前的趋势相似。然而，仍有一些特定的高患病率群体可能受益于早期发现和治疗的筛查。(C) 2008 Wiley-Liss, Inc。
Most cases of gastric cancers occur in non-industrialized countries but there is scarce information about the epidemiology of this illness in these countries. Our study examined whether there was a variation in the prevalence of gastric cancer in Lima, Peru over the last 2 decades. Subjects older than 29 years of age were included. They underwent an esophagogastroduedonoscopy at 3 socioeconomically different health facilities in Lima: a county hospital (7,168 subjects), a Peruvian-Japanese Clinic (14,794 individuals) and a private hospital (4,893 individuals). Birth cohort prevalence of gastric cancer was used. Regression models were calculated to predict the future prevalence of gastric cancer. It was found that the birth cohort prevalence of gastric cancer decreased in Peru from 22.7 to 2% (p < 0.001), from 12 to 0.5% (p < 0.001), and from 6.5 to 0.1% (p < 0.001) in the low, middle and high socioeconomic group, respectively. The prevalence of intestinal metaplasia decreased from 44.3 to 12.5% (p < 0.001), from 28.4 to 5% (p < 0.001), and from 19.4 to 2.2% (p < 0.001) in the low, middle and high socioeconomic status, respectively. These trends will likely persist over the future decades. Nevertheless, the prevalence of gastric cancer remains high in subjects older than 59 years of age in the low socioeconomic status. It is concluded that the prevalence of gastric cancer is decreasing in Peru, similar to the current trend undergoing in industrialized nations. However, there are still specific groups with high prevalence that might benefit from screening for early detection and treatment. (C) 2008 Wiley-Liss, Inc.