Serum total and free testosterone level of Japanese men: a population-based study
Serum total and free testosterone level of Japanese men: a population-based study
复制标题
DOI：
10.1111/j.1442-2042.2005.01143.x
复制
发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Shimokata, H
中科院分区：
文献类型：
--
作者：
Okamura, K;Ando, F;Shimokata, H
背景。从未对日本男性的总睾酮（TT）和游离睾酮（FT）血清水平进行过大规模的人群研究。方法。作为基于人群的衰老纵向研究的一部分，我们使用放射免疫分析 (RIA) 测定了 1120 名 40-79 岁日本男性的 TT 和 FT 血清水平。其中，还通过 RIA 对 471 名男性进行了性激素结合蛋白 (SHBG) 测量。对于后一组，通过使用白蛋白、TT 和 SHBG 血清水平的公式确定计算出的游离睾酮 (cFT)。结果。 TT、FT 和 cFT 的平均值 +/- 2 SD 分别为 513 +/- 326 ng/dL (187-839 ng/dL)、13.2 +/- 7.8) pg/mL (5.4-21.0 pg/mL) 和 77.0 +/- 43.4 pg/mL (33.6-120.4 pg/mL)。虽然 TT 与年龄无关，但 FT 和 cFT 随着年龄的增长而下降。 40-49 岁年龄组的 FT 为 15.1 +/- 8.4 pg/mL (6.7-23.5 pg/mL)，50-59 岁年龄组的 FT 为 13.9 +/- 6.8 pg/mL (7.1-20.7 pg/mL)，60-69 岁年龄组的 FT 为 12.0 +/- 6.6 pg/mL (5.4-18.6 pg/mL) 并在 70-79 岁组为 11.5 +/- 7.0 pg/mL (4.5-18.5 pg/mL)。 FT 与 cFT 显着相关（Spearman's r = 0.803）。平均-1 SD 水平的对应率为92.3%，平均-2 SD 水平的对应率为98.7%。结论。我们测定了 40 岁或以上日本男性的 TT、FT 和 cFT 的平均值和标准差。据推测，通过 RIA 测定的 FT 将有助于诊断老年男性的部分雄激素缺乏症。
Background. There has never been a large scale population-based study of serum levels of total testosterone (TT) and free testosterone (FT) in Japanese men.Methods. We determined serum levels of TT and FT of 1120 Japanese men aged 40-79 years using radioimmunoassay (RIA), as a part of a population-based longitudinal study of aging. Of these, sex hormone binding protein (SHBG) was also measured by RIA in 471 men. For the latter group, the calculated free testosterone (cFT) was determined by a formula using serum level of albumin, TT and SHBG.Ressults. The mean +/- 2 SD of TT, FT and cFT were 513 +/- 326 ng/dL (187-839 ng/dL), 13.2 +/- 7.8) pg/mL (5.4-21.0 pg/mL) and 77.0 +/- 43.4 pg/mL (33.6-120.4 pg/mL), respectively. While TT did not relate to age, FT and cFT decreased with age. FT in the 40-49 years age group was 15.1 +/- 8.4 pg/mL (6.7-23.5 pg/mL), in the 50-59 years age group was 13.9 +/- 6.8 pg/mL (7.1-20.7 pg/mL), in the 60-69 years age group was 12.0 +/- 6.6 pg/mL (5.4-18.6 pg/mL) and in the 70-79 years age group was 11.5 +/- 7.0 pg/mL (4.5-18.5 pg/mL). FT significantly correlated with cFT (Spearman's r = 0.803). The correspondence rates were 92.3% at the mean -1 SD and 98.7% at the mean -2 SD level.Conclusions. We determined the mean and standard deviation of TT, FT and cFT in Japanese men aged 40 years or older. It is supposed that FT determined by RIA would be useful for diagnosing partial androgen deficiency of aging males.