Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene
Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene
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DOI：
10.1128/aac.00185-11
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发表时间：
2011-09-01
影响因子：
4.9
通讯作者：
Balajee, S. Arunmozhi
中科院分区：
文献类型：
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作者：
Lockhart, Shawn R.;Frade, Joao P.;Balajee, S. Arunmozhi
作为ARTEMIS全球监测研究的一部分，我们调查了2008年至2009年收集的497株烟曲霉菌株对伊曲康唑、伏立康唑和泊沙康唑的MIC值升高。cyp 51 A基因测序显示，对一种或多种三唑类药物MIC值升高的29株分离株中有8株（均来自中国）含有与耐药的欧洲A.烟熏。这是第一次在欧洲以外发现TR/L98 H突变。
We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.