Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population
Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population
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中国人群中循环 miR-29b 与非酒精性脂肪肝呈正相关
DOI：
10.1111/1751-2980.12716
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发表时间：
2019-04-01
影响因子：
3.5
通讯作者：
Hu, Cheng
中科院分区：
文献类型：
--
作者：
He, Zhen;Yang, Jian Jun;Hu, Cheng
目的早期筛查非酒精性脂肪性肝病（NAFLD）对NAFLD的早期发现和干预具有重要意义。MicroRNAs （miRNAs）是包括NAFLD在内的代谢性疾病的重要调节因子。本研究的目的是调查中国人群中血清miR-29a-c与NAFLD的关系。方法根据是否存在NAFLD和/或2型糖尿病（T2DM）将参与者分为四组。采用定量聚合酶链反应分析测定血清miR-29a-c水平。评估miR-29a-c与NAFLD的相关性。结果血清miR-29b与NAFLD呈正相关，miR-29a和miR-29c与NAFLD呈正相关（比值比[or] 2.04 [1.16- 3.58], P = 0.013）。此外，年龄、血清甘油三酯和空腹血糖（FPG）水平与miR-29b独立相关（年龄的β +/-标准误差[SE] = 0.004 +/- 0.002, P = 0.019；甘油三酯的β +/- SE = 0.110 +/- 0.054, P = 0.042； FPG的β +/- SE = 0.389 +/- 0.161, P = 0.016）。经年龄、性别、体重指数校正后，MiR-29b水平与肝内脂质含量呈正相关（β +/- SE = 6.055 +/- 2.630, P = 0.024）。结论：在一项基于中国人群的研究中，血清miR-29b与肝内脂质含量和NAFLD相关。
Objective Early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for the early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic diseases including NAFLD. The aim of this study was to investigate the association of serum miR-29a-c with NAFLD in a Chinese population. Methods Participants were divided into four groups based on the presence or absence of NAFLD and/or type 2 diabetes mellitus (T2DM). Quantitative polymerase chain reaction analysis was performed to quantify serum level of miR-29a-c. The association of miR-29a-c with NAFLD was evaluated. Results Serum miR-29b, but not miR-29a or miR-29c, was positively associated with NAFLD (odds ratio [OR] 2.04 [1.16- 3.58], P = 0.013). Additionally, age, serum triglyceride and fasting plasma glucose (FPG) levels were independently associated with miR-29b (beta +/- standard error [SE] = 0.004 +/- 0.002, P = 0.019 for age; beta +/- SE = 0.110 +/- 0.054, P = 0.042 for triglyceride; and beta +/- SE = 0.389 +/- 0.161, P = 0.016 for FPG). MiR-29b level was positively correlated with intrahepatic lipid content (beta +/- SE = 6.055 +/- 2.630, P = 0.024) after adjusted for age, sex, and body mass index. Conclusions Serum miR-29b was associated with intrahepatic lipid content and NAFLD in a Chinese population-based study.