Persistency and flexibility of complex brain networks underlie dual-task interference
Persistency and flexibility of complex brain networks underlie dual-task interference
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DOI：
10.1002/hbm.22861
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发表时间：
2015-09-01
影响因子：
4.8
通讯作者：
Giessing, Carsten
中科院分区：
文献类型：
--
作者：
Alavash, Mohsen;Hilgetag, Claus C.;Giessing, Carsten
先前关于多任务处理的研究表明，并发任务处理过程中的性能下降是由于大脑模块的干扰造成的。在这里，我们使用图论网络分析来定义功能性大脑模块，并将复杂大脑网络的模块化组织与行为双任务成本联系起来。基于静息态和任务功能磁共振成像，我们探索了当人类受试者同时执行视觉空间和语音任务时可能与行为干扰相关的两个组织方面：持续单任务模块之间的拓扑重叠，以及单任务模块适应双任务条件的灵活性。与单一视觉空间任务相比，参与者在双任务中的视觉空间准确性显着下降。对模块之间拓扑相似性的全局分析表明，单任务模块之间的重叠与视觉空间准确性的下降显着相关。单任务模块之间重叠较大的受试者表现出较高的行为干扰。此外，单任务模块适应双任务条件的灵活重新配置较低与视觉空间精度的较大下降显着相关。模块灵活性较低的受试者表现出较高的行为干扰。在区域层面上，单任务模块之间较高的重叠和躯体运动皮层的模块灵活性较低与视觉空间准确性的下降呈正相关。此外，扣带和额叶控制区域的模块化灵活性较高，而包括枕中回和颞上回的右侧节点的灵活性较低，支持双任务。我们的结果表明，大脑模块的持久性和灵活性是双重任务成本的重要决定因素。我们得出的结论是，有效的双重任务受益于功能性大脑模块的灵活性和刚性之间的特定平衡。 Hum Brain Mapp 36:3542-3562, 2015。(c) 2015 Wiley periodicals, Inc.
Previous studies on multitasking suggest that performance decline during concurrent task processing arises from interfering brain modules. Here, we used graph-theoretical network analysis to define functional brain modules and relate the modular organization of complex brain networks to behavioral dual-task costs. Based on resting-state and task fMRI we explored two organizational aspects potentially associated with behavioral interference when human subjects performed a visuospatial and speech task simultaneously: the topological overlap between persistent single-task modules, and the flexibility of single-task modules in adaptation to the dual-task condition. Participants showed a significant decline in visuospatial accuracy in the dual-task compared with single visuospatial task. Global analysis of topological similarity between modules revealed that the overlap between single-task modules significantly correlated with the decline in visuospatial accuracy. Subjects with larger overlap between single-task modules showed higher behavioral interference. Furthermore, lower flexible reconfiguration of single-task modules in adaptation to the dual-task condition significantly correlated with larger decline in visuospatial accuracy. Subjects with lower modular flexibility showed higher behavioral interference. At the regional level, higher overlap between single-task modules and less modular flexibility in the somatomotor cortex positively correlated with the decline in visuospatial accuracy. Additionally, higher modular flexibility in cingulate and frontal control areas and lower flexibility in right-lateralized nodes comprising the middle occipital and superior temporal gyri supported dual-tasking. Our results suggest that persistency and flexibility of brain modules are important determinants of dual-task costs. We conclude that efficient dual-tasking benefits from a specific balance between flexibility and rigidity of functional brain modules. Hum Brain Mapp 36:3542-3562, 2015. (c) 2015 Wiley Periodicals, Inc.