SWITCH OF CD8 T-CELLS TO NONCYTOLYTIC CD8-CD4- CELLS THAT MAKE T(H)2 CYTOKINES AND HELP B-CELLS
SWITCH OF CD8 T-CELLS TO NONCYTOLYTIC CD8-CD4- CELLS THAT MAKE T(H)2 CYTOKINES AND HELP B-CELLS
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DOI：
10.1126/science.8511588
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发表时间：
1993-06-18
期刊：
影响因子：
56.9
通讯作者：
LEGROS, G
中科院分区：
文献类型：
--
作者：
ERARD, F;WILD, MT;LEGROS, G
CD 8 + T细胞是抵抗病毒感染和细胞内寄生虫的主要防御。它们产生干扰素-γ（IFN-γ）和它们的细胞溶解活性是对这些病原体的免疫应答中的关键要素。在白细胞介素-4（IL-4）存在下活化的成熟小鼠CD 8 + T细胞发育成不溶细胞且不产生IFN-γ的CD 8-CD 4-群体。然而，这些CD 8-细胞产生大量的IL-4、IL-5和IL-10，并帮助激活静息B细胞。因此，CD 8效应子功能可能是多样的，并且可以被关闭宿主保护性细胞溶解反应的感染因子利用。
CD8+ T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-gamma (IFN-gamma) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma. However, these CD8- cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.