Vitamin D-effective solar UV radiation, dietary vitamin D and breast cancer risk
Vitamin D-effective solar UV radiation, dietary vitamin D and breast cancer risk
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DOI：
10.1002/ijc.25463
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发表时间：
2011-03-15
影响因子：
6.4
通讯作者：
Lund, Eiliv
中科院分区：
文献类型：
--
作者：
Edvardsen, Kare;Veierod, Marit B.;Lund, Eiliv
众所周知，维生素D在钙和磷的体内平衡中起着重要作用。最近的研究表明，维生素D还可以预防某些类型的癌症。我们研究了太阳能维生素D有效紫外线辐射（VD剂量），饮食维生素D，阳光假期，日光浴的使用，晒伤的频率和乳腺癌的风险在一个大的人群为基础的队列研究。从1997/1998年到2007年，共有41，811名来自前瞻性挪威妇女和癌症研究的妇女，基线年龄为40-70岁。计算基线时的膳食维生素D摄入量。关于历史VD剂量的信息被用作替代获得的维生素D状态。采用考克斯比例风险模型。我们调整了年龄、身高、体重指数、基线绝经状态、激素替代疗法的使用、口服避孕药的使用、酒精、母亲的乳腺癌史、乳房X光检查和产次。在8.5年的随访期间，使用挪威癌症登记处的数据登记了948例乳腺癌新病例。我们发现VD剂量、维生素D摄入量、日光浴、日光浴或晒伤频率与乳腺癌风险之间没有显著相关性。最高与最低类别的相对风险（95%置信区间）分别为1.17（0.95-1.44）、0.95（0.75-1.21）、1.07（0.87-1.32）、0.93（0.76-1.14）和1.10（0.89-1.36）。我们的研究结果并不支持维生素D状况与乳腺癌风险之间的关联。
Vitamin D is well known for its important role in calcium and phosphor homeostasis. Recent research suggests that vitamin D also prevent some type of cancers. We studied solar vitamin D effective UV radiation (VD dose), dietary vitamin D, sun-seeking holidays, use of solarium, frequency of sunburn and breast cancer risk in a large population-based cohort study. A total of 41,811 women from the prospective Norwegian Women and Cancer Study, aged 40-70 years at baseline, were followed from 1997/1998 to 2007. Dietary vitamin D intake was calculated at baseline. Information on historical VD dose was used as a proxy for cutaneously obtained vitamin D status. Cox proportional hazards model was used. We adjusted for age, height, BMI, baseline menopausal status, use of hormone replacement therapy, use of oral contraception, alcohol, mother's history of breast cancer, mammography and parity. During 8.5 years of follow-up, 948 new cases of breast cancer were registered using data from the Norwegian Cancer Registry. We found no significant associations between VD dose, or vitamin D intake, or sun-seeking holidays, or use of solarium, or frequency of sunburn, and breast cancer risk. Relative risks (95% confidence intervals) for highest versus lowest category were 1.17 (0.95-1.44), 0.95 (0.75-1.21), 1.07 (0.87-1.32), 0.93 (0.76-1.14) and 1.10 (0.89-1.36), respectively. Our results do not support an association between vitamin D status, and breast cancer risk.