Association of Migraine and Blood Pressure-Does Obesity Severity Have a Moderating Role?
Association of Migraine and Blood Pressure-Does Obesity Severity Have a Moderating Role?
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DOI：
10.1007/s12529-023-10241-7
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发表时间：
2023-11-16
影响因子：
2.7
通讯作者：
Bond，Dale S.
中科院分区：
文献类型：
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作者：
Kalala，Siddhartha S.;Schumacher，Leah M.;Bond，Dale S.
背景偏头痛和血压 (BP) 之间的关系是模棱两可的，需要探索潜在的调节因素。肥胖与偏头痛和血压呈剂量依赖性相关，但其调节作用尚未得到评估。我们研究了患有偏头痛和肥胖的女性的偏头痛和血压之间的关系，以及这种关系是否受到肥胖严重程度的影响。方法患有偏头痛和肥胖的女性（n= 134）在随机分配到生活方式干预或偏头痛教育之前完成了 28 天的头痛日记。在完成日记之前测量血压（收缩压（SBP）/舒张压（DBP））、体重指数（BMI）和腰围（WC）。分层线性回归评估了血压与偏头痛特征（头痛频率、持续时间和疼痛强度）以及肥胖严重程度（总体 (BMI) 和腹部 (WC)）之间的关联，作为这些关联的调节因素。结果参与者 (BMI = 35.4 ± 6.5 kg/m2；WC = 105.4 ± 15.6 cm， SBP = 113.1 ± 12.1/DPB = 68.1 ± 8.0 mmHg）报告偏头痛 8.4 ± 4.5 天，持续 20.2 ± 15.9 小时，平均疼痛强度为 5.9 ± 1.6 10 分制。在总肥胖严重程度模型（β= − 0.226，p= .010）和腹部肥胖严重程度模型（β= 0.214，p= .015）中，DBP 与偏头痛天数呈负相关。收缩压和肥胖严重程度与偏头痛特征无关。肥胖严重程度并不调节偏头痛特征与血压之间的关系 (p’s > .05)。 结论 在患有偏头痛和肥胖的女性中，舒张压与偏头痛频率呈负相关；然而，肥胖严重程度并不影响这一关联或其他研究关联的强度。未来的研究需要包括健康体重控制和持续血压测量的男性和女性，以证实这些发现并确定机制和调节因素。
BackgroundThe relationship between migraine and blood pressure (BP) is equivocal, warranting exploration of potential moderators. Obesity associates with both migraine and BP in a dose-dependent fashion, although its role as a moderator has not been evaluated. We examined the relation between migraine and BP in women with comorbid migraine and obesity, and whether this relation was influenced by obesity severity.MethodsWomen with migraine and obesity (n= 134) completed a 28-day headache diary before randomization to lifestyle intervention or migraine education. BP (systolic (SBP)/diastolic (DBP)), body mass index (BMI), and waist circumference (WC) were measured before diary completion. Hierarchical linear regression assessed associations between BP and migraine characteristics (headache frequency, duration, and pain intensity), and obesity severity (both total (BMI) and abdominal (WC)) as moderators of these associations.ResultsParticipants (BMI = 35.4 ± 6.5 kg/m2; WC = 105.4 ± 15.6 cm, SBP = 113.1 ± 12.1/DPB = 68.1 ± 8.0 mmHg) reported 8.4 ± 4.5 migraine days that lasted 20.2 ± 15.9 h with mean pain intensity of 5.9 ± 1.6 on a 10-point scale. DBP inversely related to migraine days in both total (β= − 0.226,p= .010) and abdominal (β= 0.214,p= .015) obesity severity models. SBP and obesity severity did not relate to migraine characteristics. Obesity severity did not moderate relations between migraine characteristics and BP (p’s > .05).ConclusionAmong women with comorbid migraine and obesity, DBP inversely related to migraine frequency; however, obesity severity did not affect the strength of this or other examined associations. Future studies including healthy weight controls and men and women with continuous BP measures are needed to confirm these findings and identify mechanisms and moderators.