Isomer distribution of perfluorocarboxylates in human blood: Potential correlation to source
Isomer distribution of perfluorocarboxylates in human blood: Potential correlation to source
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DOI：
10.1021/es0600330
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发表时间：
2006-05-01
影响因子：
11.4
通讯作者：
Mabury, SA
中科院分区：
文献类型：
--
作者：
De Silva, AO;Mabury, SA
在人体组织中检测到ng/g水平的全氟羧酸根阴离子（PFCAs），如全氟辛酸根（C7 F15 COO-，PFOA），已引起公众对工业含氟化合物的审查。鉴于直接（工业生产）和间接（前体有机氟生产）来源，一般人群接触全氟乙酸的途径可能多种多样。有机氟（包括全氟化学品）的主要工业生产来自电化学聚合（ECF）或调聚。ECF产品是结构异构体（直链和支链全氟烷基）的混合物，并且假定调聚产品具有一种全氟化碳排列，通常为直链。本研究的目的是调查人体血液中PFCAs的结构异构体模式。采用GC-（NCI）-MS对人体血液中PFCAs的挥发性衍生物进行定量和异构体分析。全氟辛酸是主要的全氟辛酸（平均4.4纳克/克）。血清异构体谱主要由每种PFCA（C8-C11）的线性异构体组成（平均值接近98%）。ECF PFOA标准品的分支异构体模式与血液中的PFOA和PFNA具有相似性。直接暴露于ECF全氟辛酸，其中有一个传统的生产用于氟聚合物工业，被假定为所观察到的分支异构体模式的来源。线性全氟CA异构体占主导地位，血液中[偶数全氟CA] > [奇数全氟CA]的浓度趋势表明，严格的线性全氟烷基来源可能会产生额外的输入。
Detection of perfluorocarboxylate anions (PFCAs), such as perfluorooctanoate (C7F15COO-, PFOA), at ng/g levels in human tissues has engendered public scrutiny of industrial fluorochemicals. Routes of PFCA exposure for the general human population are likely diverse given direct (industrially produced) and indirect (production from precursor organofluorines) sources. Major industrial production of organofluorines, including PFCAs, stems from either electrochemical fluorination (ECF) or telomerization. ECF products are a mixture of structural isomers (linear and branched perfluoroalkyls) and telomerization products are assumed to have one perfluorocarbon arrangement, typically linear. The objective of this research was to investigate structural isomer patterns of PFCAs in human blood. Volatile derivatives of PFCAs in human blood were analyzed by GC-(NCI)-MS for quantitation and isomers. PFOA was the dominant PFCA (mean 4.4 ng/g). Blood serum isomer profiles consisted of predominantly (mean similar to 98%) the linear isomer for each PFCA (C8-C11). There were similarities in branched isomer patterns of an ECF PFOA standard with both PFOA and PFNA in blood. Direct exposure to ECF PFOA, which has a legacy of production for uses in fluoropolymer industries, is postulated to be a source of the observed branched isomer pattern. Predominance of linear PFCA isomers and the [even PFCA] > [odd PFCA] concentration trend in blood is suggestive of additional input from a strictly linear perfluoroalkyl source.