Racial and Ethnic Patterns of Allostatic Load Among Adult Women in the United States: Findings from the National Health and Nutrition Examination Survey 1999-2004
Racial and Ethnic Patterns of Allostatic Load Among Adult Women in the United States: Findings from the National Health and Nutrition Examination Survey 1999-2004
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DOI：
10.1089/jwh.2010.2170
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发表时间：
2011-04-01
影响因子：
3.5
通讯作者：
Upchurch, Dawn M.
中科院分区：
文献类型：
--
作者：
Chyu, Laura;Upchurch, Dawn M.
目的：这项研究提供了所有年龄段成年女性的异位负荷(AL)的描述性社会人口学概况，重点是AL的年龄模式如何在种族/民族之间变化。不平衡负荷是一个累积的生理失调指数，它反映了人与环境相互作用的生理应激反应的累积影响如何导致身体调节系统的磨损，进而导致疾病结局和健康差异。方法：利用1999-2004年国家健康和营养检查调查(NHANES)的数据，本研究对具有全国代表性的18岁女性样本(n=5765)进行了AL检查。使用10个代表心血管、炎症和代谢系统功能的生物标记物来衡量AL。结果：相对于其他种族/民族，黑人女性的AL预测得分最高，且在所有年龄段的AL中都存在明显的黑人/白人差距。按种族/民族划分的年龄交互作用术语显示，不同年龄组的AL模式存在显著的种族/民族差异。40-49岁的黑人女性的AL得分是50-59岁的白人女性的1.14倍，这表明健康状况恶化得更早。不在美国出生的墨西哥妇女的AL预测得分低于在美国出生的妇女。结论：这项研究提供了具有全国代表性的美国成年妇女样本中AL的首批描述性特征之一，并呈现了AL的种族/民族趋势，有助于识别具有高度累积生理失调风险的人口学和临床重要亚群。
Objective: This study provides a descriptive sociodemographic profile of allostatic load (AL) among adult women of all age groups, focusing on how age patterns of AL vary across racial/ethnic groups. Allostatic load, an index of cumulative physiological dysregulation, captures how the cumulative impact of physiological stress responses from person-environment interactions causes wear and tear on the body's regulatory systems, which in turn can lead to disease outcomes and health disparities.Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004, this study examines AL in a nationally representative sample of women 18 years of age (n = 5765). Measures of AL using 10 biomarkers representing cardiovascular, inflammatory, and metabolic system functioning were created. Multivariate negative binomial regression models were used, and predicted AL scores were computed.Results: Black women had the highest predicted AL scores relative to other racial/ethnic groups, and a marked black/white gap in AL persisted across all age groups. Age by race/ethnicity interaction terms revealed significant racial/ethnic differences in AL patterns across age groups. Black women 40-49 years old had AL scores 1.14 times higher than white women 50-59 years old, suggesting earlier health deterioration. Mexican women not born in the United States had lower predicted AL scores than those born in the United States.Conclusions: This study provides one of the first descriptive profiles of AL among a nationally representative sample of adult women in the United States and presents racial/ethnic trends in AL across age groups that are useful for identifying demographically and clinically important subgroups at risk of having high cumulative physiological dysregulation.