Decreased sensitivity to loss of options in patients with Parkinson’s disease.
Decreased sensitivity to loss of options in patients with Parkinson’s disease.
复制标题
帕金森病患者对失去选择的敏感性降低。
DOI：
10.1016/j.neuropsychologia.2022.108322
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发表时间：
2022
期刊：
影响因子：
2.6
通讯作者：
N Abe.
中科院分区：
文献类型：
--
作者：
Y Shigemune;I Kawasaki;T Baba;A Takeda;N Abe.
人类在做决定时更喜欢有多种选择。当存在选项消失的威胁时，人类会投入更多资金来保留这些选项，这表明他们对选项的丧失很敏感。这项研究调查了帕金森病（PD）患者是否在选择消失时尝试保留可用的选择，帕金森病是一种以多巴胺耗竭为特征的疾病。 27 名没有痴呆的帕金森病患者和 27 名健康对照者 (HC) 进行了门游戏，其中参与者以三扇门的形式呈现多种选择，每扇门都与不同的点分布相关。参与者被要求通过找到最好的门来最大化他们的积分收入。该任务包括两个条件。在百叶窗状态下，百叶窗逐渐关闭未选择的门；一旦百叶窗完全关闭，门就不再可用。控制条件下没有百叶窗。结果显示，HC 在百叶窗条件下比在控制条件下更频繁地开关门，这表明倾向于保留可用选项。然而，PD 患者在两种情况下并没有表现出这种差异。通过 123 I-ioflupane-SPECT (DaTSCAN) 图像测量，PD 患者中快门和控制条件之间的切换次数差异与左侧纹状体中多巴胺转运蛋白的分布显着正相关。这些结果表明PD患者对选择的丧失不太敏感，这种敏感性的降低可能是由多巴胺能神经传递下降引起的。
Humans prefer to have many options when making decisions. When there is a threat of options disappearing, humans invest more to keep these options available, indicating that they are sensitive to the loss of options. This study examined whether patients with Parkinson's disease (PD), a disease characterized by dopamine depletion, try to keep options available when options are disappearing. Twenty-seven PD patients without dementia and 27 healthy controls (HCs) performed the door game, in which participants were presented with multiple alternatives in the form of three doors, each associated with a different point distribution. The participants were asked to maximize their point earnings by finding the best door. The task included two conditions. In the shutter condition, shutters gradually closed on doors that were not chosen; once the shutters completely closed, the door was no longer available. There were no shutters in the control condition. The results revealed that the HCs switched doors more often in the shutter condition than in the control condition, indicating a tendency to keep options available. However, the PD patients did not show such differences between the two conditions. The difference in the number of switches between the shutter and control conditions in the PD patients was significantly positively correlated with the distribution of dopamine transporters in the left striatum, as measured by123I-ioflupane-SPECT (DaTSCAN) images. These results suggest that PD patients are less sensitive to the loss of options, and this decreased sensitivity may be caused by a decline in dopaminergic neurotransmission.