Role of the Cytokinin-Activated Type-B Response Regulators in Hormone Crosstalk
Role of the Cytokinin-Activated Type-B Response Regulators in Hormone Crosstalk
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DOI：
10.3390/plants9020166
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Y. Zubo;G. Schaller
中科院分区：
文献类型：
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作者：
Y. Zubo;G. Schaller
细胞分裂素是一种重要的植物激素，它通过一个多步骤的磷酸传递途径将信号从受体传递到细胞核，最终激活作为转录因子的B型反应调节因子。最近的染色质免疫沉淀测序(CHIP-SEQ)研究已经确定了B型拟南芥反应调节因子(ARRs)的靶标，并将这些靶标整合到细胞分裂素激活的转录网络中。B型ARR的主要靶点是与激素调节有关的基因，强调细胞分裂素、生长素、脱落酸、油菜素类固醇、赤霉酸、乙烯、茉莉酸和水杨酸之间可能存在广泛的串扰。对激素相关靶点的研究揭示了包括生物合成、降解/失活、运输和信号转导在内的多个调节点。在这里，我们从涉及的激素、调节串音点和生理意义的角度来考虑这种对细胞分裂素的早期反应。
Cytokinin is an important phytohormone that employs a multistep phosphorelay to transduce the signal from receptors to the nucleus, culminating in activation of type-B response regulators which function as transcription factors. Recent chromatin immunoprecipitation-sequencing (ChIP-seq) studies have identified targets of type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs) and integrated these into the cytokinin-activated transcriptional network. Primary targets of the type-B ARRs are enriched for genes involved in hormonal regulation, emphasizing the extensive crosstalk that can occur between cytokinin, auxin, abscisic acid, brassinosteroids, gibberellic acid, ethylene, jasmonic acid, and salicylic acid. Examination of hormone-related targets reveals multiple regulatory points including biosynthesis, degradation/inactivation, transport, and signal transduction. Here, we consider this early response to cytokinin in terms of the hormones involved, points of regulatory crosstalk, and physiological significance.