Cutting Edge: Tissue-Resident Memory T Cells Generated by Multiple Immunizations or Localized Deposition Provide Enhanced Immunity
Cutting Edge: Tissue-Resident Memory T Cells Generated by Multiple Immunizations or Localized Deposition Provide Enhanced Immunity
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DOI：
10.4049/jimmunol.1601367
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发表时间：
2017-03-15
影响因子：
4.4
通讯作者：
Mackay, Laura K.
中科院分区：
文献类型：
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作者：
Davies, Brooke;Prier, Julia E.;Mackay, Laura K.
组织驻留记忆T细胞（TRM）已被证明提供针对感染的上级保护，特别是针对经由身体的上皮表面进入的病原体。虽然TRM通常集中在先前感染的部位，但已显示TRM可在全身传播。我们检查了皮肤中整体与靶向CD8（+）TRM沉积的相对有效性。初始T细胞引发的位点对皮肤沉积没有什么影响，而局部炎症和Ag识别增强了TRM的积累和保留。在皮肤中观察到播散性TRM沉积，但需要多次暴露于Ag，且劣于靶向策略。因此，通过炎症或感染进行的主动募集导致了上级的TRM数量和最大的抗感染保护。总体而言，这些结果突出了局部TRM沉积作为病原体控制手段的效力，并证明了全球TRM沉积的局限性。
Tissue-resident memory T cells (TRM) have been shown to afford superior protection against infection, particularly against pathogens that enter via the epithelial surfaces of the body. Although TRM are often concentrated at sites of prior infection, it has been shown that TRM can disseminate throughout the body. We examined the relative effectiveness of global versus targeted CD8(+) TRM lodgment in skin. The site of initial T cell priming made little difference to skin lodgement, whereas local inflammation and Ag recognition enhanced TRM accumulation and retention. Disseminated TRM lodgment was seen with the skin, but required multiple exposures to Ag and was inferior to targeted strategies. As a consequence, active recruitment by inflammation or infection resulted in superior TRM numbers and maximal protection against infection. Overall, these results highlight the potency of localized TRM deposition as a means of pathogen control as well as demonstrating the limitations of global TRM lodgment.