Cancer of mouth, pharynx and nasopharynx in Asian and Chinese immigrants resident in Thames regions
Cancer of mouth, pharynx and nasopharynx in Asian and Chinese immigrants resident in Thames regions
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DOI：
10.1016/s1368-8375(99)00019-6
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发表时间：
1999-09-01
期刊：
影响因子：
4.8
通讯作者：
Bell, J
中科院分区：
文献类型：
--
作者：
Warnakulasuriya, KAAS;Johnson, NW;Bell, J
对移民的研究可以为癌症的病因学提供重要线索。本研究的目的是确定种族来源与英格兰南部泰晤士河地区居民口腔和咽癌发病率之间的关系。研究人员检查了泰晤士河癌症登记处1986-91年期间的记录，并用出生地和姓名标记了南亚人和华裔移民。头颈癌相对发病率(n=7222)的计算表明，口腔癌在亚洲人(95/232=40.9%)和中国人鼻咽癌(45/67=67.2%)中显著高于亚洲人(95/232=40.9%)。癌症的口腔内部位和种族来源也有一些差异。在确诊癌症时，少数民族移民(亚洲人51.6+/-34.8岁，中国人47.6+/-14.8岁)与其他人口(64.8+/-15.6岁)相比明显年轻(p=0.0)，但在表现阶段方面没有发现显著差异。头颈部癌症的平均生存期为2.2年，三组患者的累积存活率有显著差异(p=0.003)。口腔癌的发病率与亚裔居民比例较高的地方当局之间有很强的相关性。南亚和中国少数民族是口腔和鼻咽癌的重要高危群体，对他们进行有针对性的预防。(C)1999爱思唯尔科学有限公司。保留所有权利。
Studies on migrants can generate important clues on the etiology of cancer. The purpose of the present study was to determine the relationship between ethnic origin and the incidence of oral and pharyngeal cancers among residents of the Thames regions in southern England. Records from the Thames Cancer Registry during the period 1986-91 were examined and south Asians and Chinese ethnic immigrants flagged using their place of birth and names. Computation of relative incidence among head and neck cancers (n = 7222) showed that oral cancer was significantly higher among Asians (95/232 = 40.9%) and nasopharyngeal cancer among Chinese (45/67 = 67.2%). Some differences in the intra-oral site of cancer and ethnic origin were noted. The ethnic migrants were significantly younger (Asians 51.6 +/- 34.8 years, Chinese 47.6 +/- 14.8 years) compared to the rest of the population (64.8 +/- 15.6 years) at the time of cancer diagnosis (p = 0.0) but no significant differences were found for the stage of presentation. The mean survival period for a cancer of the head and neck was 2.2 years and significant differences in cumulative rates of survival were noted among the three groups studied (p = 0.003). A strong correlation was noted between the incidence of oral cancer and local authorities with a high percentage of Asian residents. The south Asian and Chinese ethnic minorities constitute important high risk groups for oral and nasopharyngeal cancer, for whom targeted prevention is indicated. (C) 1999 Elsevier Science Ltd. All rights reserved.