Analyses of placental gene expression in pregnancy-related hypertensive disorders
Analyses of placental gene expression in pregnancy-related hypertensive disorders
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DOI：
10.1016/j.tjog.2011.07.005
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发表时间：
2011-09-01
影响因子：
2.1
通讯作者：
Wang, Tzu-Hao
中科院分区：
文献类型：
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作者：
Chang, Shuenn-Dyh;Chao, An-Shine;Wang, Tzu-Hao
目的：探讨子痫前期与慢性高血压叠加子痫前期妇女胎盘基因表达的变化。材料与方法：在台湾人群中，比较子痫前期与慢性高血压叠加子痫前期患者胎盘的基因表达量。结果：虽然子痫前期与慢性高血压叠加子痫前期的顶级激活基因有所不同，但功能网络分析表明这些基因主要参与子痫前期的调控。细胞死亡和凋亡。这些结果表明胎盘中的细胞凋亡和其他类型的细胞死亡是这两种疾病的常见后果。然而，胎盘内皮糖蛋白（ENG）在先兆子痫中的表达水平显着高于叠加先兆子痫。功能网络分析结果表明，ENG可能通过干扰内皮一氧化氮合酶引起的血管舒张而在子痫前期的发病机制中发挥作用。结论：我们的结果支持了ENG是子痫前期发生的罪魁祸首的事实。此外，这项研究还确定了胎盘中的其他几个基因，这些基因在妊娠相关高血压中受到转录调节。版权所有(C) 2011，台湾妇产科学会。由爱思唯尔台湾有限公司出版。版权所有。
Objective: To explore the changes in placental gene expression between women with preeclampsia and those with superimposed preeclampsia on chronic hypertension.Materials and Methods: In Taiwanese population, we compared gene expression between the placentas from preeclamptic patients and those with superimposed preeclampsia on chronic hypertension.Results: Although top-ranked activated genes between preeclampsia and superimposed preeclampsia on chronic hypertension were different, functional network analyses indicate that these genes are mainly involved in the regulation of cell death and apoptosis. These results suggest that apoptosis and other types of cell death in the placenta are common consequences of both diseases. However, placental endoglin (ENG) was expressed at a significantly higher level in preeclampsia than in superimposed preeclampsia. Results of functional network analysis indicated that ENG may play a role in the pathogenesis of preeclampsia through its interference with the endothelial nitric oxide synthase-reaulated vasodilation.Conclusion: Our results support the fact that ENG is the culprit for the development of preeclampsia. In addition, this study identifies several other genes in the placenta, which are transcriptionally regulated in pregnancy-related hypertensions. Copyright (C) 2011, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.