Risk factors for increased bone loss in an elderly population - The Rotterdam Study
Risk factors for increased bone loss in an elderly population - The Rotterdam Study
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DOI：
10.1093/oxfordjournals.aje.a009541
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发表时间：
1998-05-01
影响因子：
5
通讯作者：
Pols, HAP
中科院分区：
文献类型：
--
作者：
Burger, H;de Laet, CEDH;Pols, HAP
鹿特丹研究（荷兰一项基于人群的队列研究）对年龄 55 岁及以上的 1,856 名男性和 2,452 名女性进行了研究，研究了骨质流失与年龄、性别以及骨质疏松症的几种常见和可改变的潜在危险因素的关系。股骨颈骨矿物质密度的变化率是在 1990 年至 1995 年间，平均随访 2 年之后进行纵向估计的。根据年龄和体重指数进行调整后，男性的这些比率为 -0.0025（95% 置信区间 -0.0038 至 -0.0012），男性为 -0.0045（95% 置信区间 -0.0056 至 -0.0034）。女性的 g/cm(2)/年（p = 0.03）。骨质流失随着年龄的增长而加速，男性比女性更明显。较低的体重指数和吸烟与男性和女性的巴恩损失增加有关。在男性中，较高的钙摄入量与较低的骨丢失率相关，而残疾与临界显着较高的骨丢失率相关（p = 0.07）。在女性中，观察到与残疾的不显着关系，但与膳食钙摄入量无关。无论男女，酒精摄入量与骨质流失率的关系并不总是一致。结论是老年人骨质流失率女性更高？随着年龄的增长而进展，并进一步由几个可改变的危险因素决定，特别是在男性中。
The association of bone loss with age, sex, and several prevalent and modifiable potential risk factors for osteoporosis was studied in 1,856 men and 2,452 women aged 55 years and over from the Rotterdam Study, a population-based cohort study in the Netherlands. The rate of change in femoral neck bone mineral density was estimated longitudinally between 1990 and 1995, after 2 years of follow-up on average, These rates, adjusted for age and body mass index, were -0.0025 (95% confidence interval -0.0038 to -0.0012) in men and -0.0045 (95% confidence interval -0.0056 to -0.0034) g/cm(2)/year in women (p = 0.03). Bone loss accelerated with age, as seen more clearly in men than in women. Lower body mass index and cigarette smoking were associated with increased bane loss in both men and women. In men, higher calcium intake was associated with lower rates, and disability was associated with borderline significantly higher rates of bone loss (p = 0.07), In women, a nonsignificant relation was observed with disability, but not with dietary calcium intake. Alcohol intake was not consistently related to the rate of bone loss in either sex. It is concluded that in elderly people the rate of bone loss is higher in women? progresses with age, and is further determined by several modifiable risk factors, particularly in men.