Testosterone metabolism by serially subcultured fibroblasts from genital and nongenital skin of individual human donors.
Testosterone metabolism by serially subcultured fibroblasts from genital and nongenital skin of individual human donors.
复制标题
来自人类捐献者生殖器和非生殖器皮肤的连续传代培养的成纤维细胞的睾酮代谢。
DOI：
10.1016/s0006-291x(72)80147-5
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发表时间：
1972
影响因子：
3.1
通讯作者：
George Hall
中科院分区：
文献类型：
--
作者：
L. Pinsky;R. Finkelberg;C. Straisfeld;Barbara Zilahi;M. Kaufman;George Hall
从3只雄性小鼠的包皮和三角肌区以及2只雌性小鼠的大阴唇和腹部培养皮肤成纤维细胞。生殖器皮肤菌株比非生殖器皮肤菌株代谢睾丸激素的速度快得多。这是第一次清楚地证明，在连续继代培养的细胞中，人类非恶性体细胞组织之间的代谢差异持续存在。
Skin fibroblasts were cultured from the prepuce and deltoid area of three males, and from the labia majora and abdomen of two females. The genital skin strains metabolised testosterone much faster than those derived from nongenital skin. This is the first clear demonstration of the persistence in serially subcultured cells of a metabolic difference between nonmalignant somatic tissues of human beings.