TGF-β signaling in C. elegans.
TGF-β signaling in C. elegans.
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秀丽隐杆线虫中的TGF-β信号传导。
DOI：
10.1895/wormbook.1.22.2
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发表时间：
2013-07-10
期刊：
影响因子：
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通讯作者：
Savage-Dunn C
中科院分区：
文献类型：
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作者：
Gumienny TL;Savage-Dunn C
在多细胞动物中，转化生长因子-β (TGF-β)超家族配体调节细胞身份、功能和存活的许多方面。编码5个TGF-β家族成员的基因存在于秀丽隐杆线虫基因组中。其中两个配体DBL-1和DAF-7通过典型受体- smad信号通路发出信号；而第三种配体UNC-129则与非典型信号通路相互作用。没有任何功能与剩下的两个配体有关。本文就这些信号通路及其生物学功能进行综述。
Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell identity, function, and survival in multicellular animals. Genes encoding five TGF-β family members are present in the genome of C. elegans. Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway. No function has yet been associated with the remaining two ligands. Here we summarize these signaling pathways and their biological functions.