Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging
Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging
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DOI：
10.1364/oe.22.026365
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发表时间：
2014-10-20
期刊：
影响因子：
3.8
通讯作者：
Steenbergen, W.
中科院分区：
文献类型：
--
作者：
Daoudi, K.;van den Berg, P. J.;Steenbergen, W.
超声和光声可以作为补充成像技术来改善临床诊断。光声提供光学对比和功能信息，而超声提供结构和解剖信息。到目前为止，光声成像使用大型且昂贵的系统，这限制了它们的临床应用，并且使得组合昂贵且不切实际。在这项工作中，我们提出并评估了一个紧凑的和符合人体工程学设计的手持探头，连接到一个便携式超声系统，廉价，实时双模态超声/光声成像。该探头集成了超声换能器阵列和高效二极管堆激光器，该二极管堆激光器在805 nm波长处发射130 ns脉冲，脉冲能量为0.56 mJ，高脉冲重复频率高达10 kHz。二极管由定制的激光驱动器驱动，该激光驱动器可以外部触发，具有同步超声检测和激光脉冲所需的高时间稳定性。所发射的光束用圆柱形微透镜准直，并使用衍射光学元件成形，从而提供均匀的矩形光强度分布。系统性能进行了测试，在体外和体内成像人体手指关节。(C)2014年美国光学学会
Ultrasound and photoacoustics can be utilized as complementary imaging techniques to improve clinical diagnoses. Photoacoustics provides optical contrast and functional information while ultrasound provides structural and anatomical information. As of yet, photoacoustic imaging uses large and expensive systems, which limits their clinical application and makes the combination costly and impracticable. In this work we present and evaluate a compact and ergonomically designed handheld probe, connected to a portable ultrasound system for inexpensive, real-time dual-modality ultrasound/photoacoustic imaging. The probe integrates an ultrasound transducer array and a highly efficient diode stack laser emitting 130 ns pulses at 805 nm wavelength and a pulse energy of 0.56 mJ, with a high pulse repetition frequency of up to 10 kHz. The diodes are driven by a customized laser driver, which can be triggered externally with a high temporal stability necessary to synchronize the ultrasound detection and laser pulsing. The emitted beam is collimated with cylindrical micro-lenses and shaped using a diffractive optical element, delivering a homogenized rectangular light intensity distribution. The system performance was tested in vitro and in vivo by imaging a human finger joint. (C) 2014 Optical Society of America