NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities
NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities
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DOI：
10.1038/ja.2009.15
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Wu, Wenjun
中科院分区：
文献类型：
--
作者：
Guo, Zhengyan;Shen, Ling;Wu, Wenjun
采用大孔树脂、硅胶柱层析和高效液相色谱从菌株313的发酵液中分离得到一种新的环状六肽类抗生素NW-G01。根据产生菌的形态特征、生理特性和16S rDNA基因序列分析，确定该菌株为白色链霉菌。NW-G01对枯草芽孢杆菌、蜡状芽孢杆菌、金黄色葡萄球菌、甲氧西林耐药金黄色葡萄球菌有较强的抗菌活性，其MIC值分别为3.90、3.90、7.81和7.81 mU·g·m l~(-1)。《抗生素杂志》(2009年)62,2012205；doi：10.1038/ja.2009.15；2009年3月6日在线发布
NW-G01, a novel cyclic hexadepsipeptide antibiotic, was isolated by macroporous resin and silica gel column chromatography and HPLC from the fermentation broth of strain no. 313. The producing strain was identified as Streptomyces alboflavus on the basis of the morphological characteristics, physiological property and 16S rDNA gene sequence analysis. NW-G01 exhibited strong antibacterial activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, methicillin-resistant S. aureus, and their MIC values were 3.90, 3.90, 7.81 and 7.81 mu g ml(-1), respectively. The Journal of Antibiotics (2009) 62, 201-205; doi:10.1038/ja.2009.15; published online 6 March 2009