Cholesterol efflux by high density lipoproteins is impaired in patients with active rheumatoid arthritis.
Cholesterol efflux by high density lipoproteins is impaired in patients with active rheumatoid arthritis.
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DOI：
10.1136/annrheumdis-2011-200493
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发表时间：
2012-07
影响因子：
27.4
通讯作者：
Reddy ST
中科院分区：
文献类型：
--
作者：
Charles-Schoeman C;Lee YY;Grijalva V;Amjadi S;FitzGerald J;Ranganath VK;Taylor M;McMahon M;Paulus HE;Reddy ST
胆固醇反向转运（RCT）是高密度脂蛋白（HDL）的主要抗动脉粥样硬化功能。在当前的工作中，作者评估了与健康对照相比，类风湿性关节炎 (RA) 患者的 HDL 的 RCT 能力是否受损。 HDL 是从 40 名 RA 患者和 40 名年龄和性别匹配的健康对照中分离出来的。如前所述进行胆固醇流出、HDL 的抗氧化功能和对氧烷酶-1 (PON-1) 活性的测定。通过市售测定法评估血浆髓过氧化物酶（MPO）活性。 HDL平均胆固醇流出能力在RA患者（40.2%±11.1%）和对照组（39.5%±8.9%）之间没有显着差异； p=0.75。然而，与疾病活动/临床缓解极低的患者的 HDL (DAS28<2.6) 相比，通过使用 28 个关节计数的疾病活动评分 (DAS28>5.1) 测量的疾病活动度高的 RA 患者的 HDL 促进胆固醇流出的能力显着降低。胆固醇流出与 DAS28 (r=-0.39，p=0.01) 和红细胞沉降率 (r=-0.41，p=0.0009) 之间存在显着相关性。较高的血浆 MPO 活性与较差的 HDL 功能相关（r=0.41/p=0.009（抗氧化能力）；r=0.35，p=0.03（流出））。 HDL 促进胆固醇流出的能力与其抗氧化功能有适度但显着的相关性（r=-0.34，p=0.03）。在疾病活动度较高的 RA 患者中，HDL 的胆固醇流出能力受损，并且与全身炎症和 HDL 的抗氧化能力相关。 HDL 功能的减弱与 HDL 胆固醇水平无关，可能表明活性 RA 导致心血管 (CV) 风险增加的机制。
Reverse cholesterol transport (RCT) is a major antiatherogenic function of high density lipoprotein (HDL). In the current work, the authors evaluated whether the RCT capacity of HDL from rheumatoid arthritis (RA) patients is impaired when compared to healthy controls. HDL was isolated from 40 patients with RA and 40 age and sex matched healthy controls. Assays of cholesterol efflux, HDL’s antioxidant function and paraoxanase-1 (PON-1) activity were performed as described previously. Plasma myeloperoxidase (MPO) activity was assessed by a commercially available assay. Mean cholesterol efflux capacity of HDL was not significantly different between RA patients (40.2%±11.1%) and controls (39.5%±8.9%); p=0.75. However, HDL from RA patients with high disease activity measured by a disease activity score using 28 joint count (DAS28>5.1), had significantly decreased ability to promote cholesterol efflux compared to HDL from patients with very low disease activity/clinical remission (DAS28<2.6). Significant correlations were noted between cholesterol efflux and the DAS28 (r=−0.39, p=0.01) and erythrocyte sedimentation rate, (r=−0.41, p=0.0009). Higher plasma MPO activity was associated with worse HDL function (r=0.41/p=0.009 (antioxidant capacity); r=0.35, p=0.03 (efflux)). HDL’s ability to promote cholesterol efflux was modestly but significantly correlated with its antioxidant function (r=−0.34, p=0.03). The cholesterol efflux capacity of HDL is impaired in RA patients with high disease activity and is correlated with systemic inflammation and HDL’s antioxidant capacity. Attenuation of HDL function, independent of HDL cholesterol levels, may suggest a mechanism by which active RA contributes to increased cardiovascular (CV) risk.
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影响因子：
3.1
作者：
Feijoo, Montserrat;Tunez, Isaac;Collantes, Eduardo
通讯作者：
Collantes, Eduardo
影响因子：
--
作者：
Charles-Schoeman, Christina;Watanabe, Junji;Reddy, Srinivasa T.
通讯作者：
Reddy, Srinivasa T.
DOI：
10.1073/pnas.0802025105
发表时间：
2008-08-26
影响因子：
11.1
作者：
Shao, Baohai;Cavigiolio, Giorgio;Heinecke, Jay W.
通讯作者：
Heinecke, Jay W.
影响因子：
--
作者：
del Rincón, I;Williams, K;Escalante, A
通讯作者：
Escalante, A
影响因子：
4.6
作者：
Filippin, L. I.;Vercelino, R.;Xavier, R. M.
通讯作者：
Xavier, R. M.