Projection from the ventral bed nucleus of the stria terminalis to the retrorubral field in rats and the effects of cells in these areas on mating in male rats versus gerbils
Projection from the ventral bed nucleus of the stria terminalis to the retrorubral field in rats and the effects of cells in these areas on mating in male rats versus gerbils
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DOI：
10.1016/j.yhbeh.2004.08.008
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Yahr, P
中科院分区：
文献类型：
--
作者：
Finn, PD;Yahr, P
本研究确定了沙土鼠内侧视前区(MPOA)内侧性二形区(SDA)细胞群的大鼠对应体。外侧SDA(ISDA)对于雄性沙土鼠的交配是至关重要的，它含有大部分投射到腰后野(RRF)的SDA细胞，这一投射对交配也很重要。因此，为了定位外侧SDA的对应物，我们追踪了大鼠终纹床核腹侧部分密集的RRF的输入。为了确定腹侧BST或其向RRF的投射是否影响雄性大鼠的交配，我们通过在腹侧BST或单侧BST和对侧RRF放置胞体损伤来破坏它们。我们还研究了RRF对大鼠和沙土鼠损伤的影响。双侧腹侧BST损伤使内侧视前核完好无损，导致持续严重的交配缺陷。切断腹侧BST与RRF的连接也有长期的，但不那么严重的后果。RRF损伤只在大鼠中产生了暂时性的交配缺陷，但在沙土鼠中几乎消除了交配。损毁RRF后大鼠交配的恢复，但不包括腹侧BST，以及这些区域相互断开的中间效应表明，腹侧BST可能含有与交配相关的投射神经元，而不是投射到RRF的投射神经元，或者其RRF投射细胞将侧支发送到另一个部位。在任何一种情况下，都可能累及桥小脑脚被盖核或中缝核。(C)2004 Elsevier Inc.保留所有权利。
This research identified the rat counterpart of the lateral cell group of the sexually dimorphic area (SDA) found in medial preoptic area (MPOA) gerbil of gerbils. The lateral SDA (ISDA) is critical for mating in male gerbils and contains most of the SDA cells projecting to the retrorubral field (RRF), a projection that is also important for mating. Therefore, to locate the counterpart of the lateral SDA, we traced the inputs to the rat RRF, which were dense in the ventral part of the bed nucleus of the stria terminalis (BST). To determine if the ventral BST or its projection to the RRF affects mating in male rats, we disrupted them bilaterally by placing cell-body lesions bilaterally in the ventral BST or unilaterally there and in the contralateral RRF. We also studied the effects of RRF lesions in both rats and gerbils. Bilateral ventral BST lesions, which left the medial preoptic nucleus intact, produced persistent and severe mating deficits. Disconnecting the ventral BST from the RRF also had long-lasting, but less severe, consequences. RRF lesions produced only temporary mating deficits in rats, but virtually eliminated mating in gerbils. The recovery of mating in rats after RRF, but not ventral BST, lesions, and the intermediate effects of disconnecting these areas from each other suggest that the ventral BST may contain mating-related projection neurons other than those projecting to the RRF or that its RRF-projecting cells send collaterals to another site. In either case, the pedunculopontine tegmental nucleus or raphe nuclei may be involved. (C) 2004 Elsevier Inc. All rights reserved.