The Molecular Revolution in Cutaneous Biology: EDC and Locus Control.
The Molecular Revolution in Cutaneous Biology: EDC and Locus Control.
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皮肤生物学的分子革命：EDC 和基因座控制。
DOI：
10.1016/j.jid.2016.03.046
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
deGuzmanStrong,Cristina
中科院分区：
文献类型：
--
作者：
Oh,InezY;deGuzmanStrong,Cristina
The epidermal differentiation complex (EDC) locus consists of a cluster of genes important for the terminal differentiation of the epidermis. While early studies identified the functional importance of individual EDC genes, the recognition of the EDC genes as a cluster with its shared biology, homology, and physical linkage was pivotal to later studies that investigated the transcriptional regulation of the locus. Evolutionary conservation of the EDC and the transcriptional activation during epidermal differentiation suggested a cis-regulatory mechanism via conserved noncoding elements or enhancers. This line of pursuit led to the identification of CNE 923, an epidermal-specific enhancer that was found to mediate chromatin remodeling of the EDC in an AP-1 dependent manner. These genomic studies, as well as the advent of high-throughput sequencing and genome engineering techniques, have paved the way for future investigation into enhancer-mediated regulatory networks in cutaneous biology.
