Extracellular Matrix Components Regulate Cellular Polarity and Tissue Structure in the Developing and Mature Retina.
Extracellular Matrix Components Regulate Cellular Polarity and Tissue Structure in the Developing and Mature Retina.
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DOI：
10.4103/2008-322x.170354
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发表时间：
2015-07
影响因子：
2
通讯作者：
Brunken WJ
中科院分区：
文献类型：
--
作者：
Varshney S;Hunter DD;Brunken WJ
虽然遗传网络和其他内在机制调节大部分视网膜发育，但与细胞外环境的相互作用塑造了这些网络并改变了它们的输出。本综述重点关注细胞外基质分子家族及其在视网膜发育中的信号通路的作用。除了对视网膜发育的影响外，层粘连蛋白还在维持穆勒细胞极性和区室化方面发挥作用，从而有助于视网膜稳态。本文面向临床读者，回顾了视网膜发育的基础知识、细胞外基质组织以及层粘连蛋白在视网膜发育中的作用。还简要讨论了层粘连蛋白在皮质发育中的作用。
While genetic networks and other intrinsic mechanisms regulate much of retinal development, interactions with the extracellular environment shape these networks and modify their output. The present review has focused on the role of one family of extracellular matrix molecules and their signaling pathways in retinal development. In addition to their effects on the developing retina, laminins play a role in maintaining Müller cell polarity and compartmentalization, thereby contributing to retinal homeostasis. This article which is intended for the clinical audience, reviews the fundamentals of retinal development, extracellular matrix organization and the role of laminins in retinal development. The role of laminin in cortical development is also briefly discussed.