Nationwide survey of rotavirus-associated encephalopathy and sudden unexpected death in Japan
Nationwide survey of rotavirus-associated encephalopathy and sudden unexpected death in Japan
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DOI：
10.1016/j.braindev.2013.07.013
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发表时间：
2014-08-01
影响因子：
1.7
通讯作者：
Yoshikawa, Tetsushi
中科院分区：
文献类型：
--
作者：
Kawamura, Yoshiki;Ohashi, Masahiro;Yoshikawa, Tetsushi
背景：轮状病毒可引起脑病/脑炎和意外死亡等严重并发症。轮状病毒相关脑病/脑炎或意外死亡的发生率仍不清楚。为了明确轮状病毒相关脑炎/脑病和意外死亡的临床特征，我们在日本进行了全国范围的调查。方法：设计两部分问卷调查，了解2009年至2011年间轮状病毒感染重症病例（包括脑炎/脑病和意外死亡）的病例数和临床特征。结果：向医院发送的1365份问卷中，回收963份（70.5%）并符合分析条件。我们确定了 58 例轮状病毒相关脑炎/脑病病例和 7 例意外死亡病例。这些患者通过免疫层析诊断为轮状病毒感染。尽管36/58（62.1%）脑炎/脑病患者没有后遗症，但15/58（25.9%）患者出现神经系统后遗症，7/58（12.1%）患者出现致命结果。 9/40 (22.5%) 的患者观察到细胞增多，仅 4/40 (10%) 的患者脑脊液蛋白水平升高。乳酸脱氢酶（LDH）升高（>500 IU/L）或酸血症（pH 500 IU/L）或酸血症（pH < 7.15）与脑炎/脑病的不良预后相关。 (C) 2013 年日本儿童神经病学学会。由 Elsevier B.V. 出版。保留所有权利。
Background: Rotavirus can cause severe complications such as encephalopathy/encephalitis and sudden unexpected death. The incidence of rotavirus-associated encephalopathy/encephalitis or sudden unexpected death remains unknown. To clarify the clinical features of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death, we conducted a nationwide survey in Japan. Method: A two-part questionnaire was designed to determine the number of the cases and the clinical features of severe cases of rotavirus infection, including encephalitis/encephalopathy and sudden unexpected death, between 2009 and 2011. Result: Of the 1365 questionnaires sent to hospitals, 963 (70.5%) were returned and eligible for analysis. We determined 58 cases of rotavirus-associated encephalitis/encephalopathy and 7 cases of sudden unexpected death. These patients were diagnosed with rotavirus infection by immunochromatography. Although 36/58 (62.1%) encephalitis/encephalopathy patients had no sequelae, 15/58 (25.9%) patients had neurological sequelae, and 7/58 (12.1%) patients had fatal outcomes. Pleocytosis was observed in 9/40 (22.5%) patients and cerebrospinal fluid protein levels were elevated in only 4/40 (10%) patients. Elevated lactate dehydrogenase (LDH) (>500 IU/L) or acidemia (pH 500 IU/L) or acidemia (pH < 7.15) were related to a poor prognosis of the encephalitis/encephalopathy. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.