Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate
Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate
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DOI：
10.1111/jcpe.12067
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发表时间：
2013-05-01
影响因子：
6.7
通讯作者：
Romito, Giuseppe A.
中科院分区：
文献类型：
--
作者：
Chambrone, Leandro;Foz, Adriana M.;Romito, Giuseppe A.
目的本系统评价（SR）的目的是评价牙周炎与慢性肾脏病（CKD）之间的关系以及牙周治疗（PT）对估计肾小球滤过率（eGFR）的影响。方法计算机检索MEDLINE、EMBASE和科克伦中心对照试验数据库（CENTRAL）中关于慢性牙周病与牙周炎相关性的观察性（S1）和干预性（S2）研究，时间截止至2012年9月30日。如果研究报告了eGFR，则认为它们有资格入选。由两名独立审查员进行检索。使用适用于本综述的Newcastle-Ottawa量表（NOS）和科克伦协作组偏倚风险评估工具评估观察性研究的方法学质量。进行随机效应比值比荟萃分析，以估计牙周炎和CKD之间的关联程度。结果检索策略确定了2456篇潜在合格的文章，其中包括4个横断面研究，1个回顾性研究和3个干预性研究。4例S1，80.0%报告牙周炎与CKD之间存在一定程度的相关性。类似地，这样的结果得到了汇总估计值的支持（OR：1.65，95%置信区间：1.35，2.01，p
Aim The aim of this systematic review (SR) was to evaluate the association between periodontitis and chronic kidney disease (CKD) and the effect of periodontal treatment (PT) on the estimated glomerular filtration rate (eGFR). Methods MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched up to and including September 30, 2012 to observational (S1) and interventional (S2) studies on the association of periodontitis with CKD. Studies were considered eligible for inclusion if they reported the eGFR. Search was conducted by two independent reviewers. The methodological quality of the observational studies was assessed using the Newcastle-Ottawa Scale (NOS) adapted for this review, and the Cochrane's Collaboration risk of bias assessment tool. A random-effects odds-ratio meta-analysis was conducted to estimate the degree of association between periodontitis and CKD. Results Search strategy identified 2456 potentially eligible articles, of which four cross-sectional, one retrospective, and three interventional studies were included. Four S1, 80.0% reported some degree of association between periodontitis and CKD. Similarly, such an outcome was supported by pooled estimates (OR: 1.65, 95% Confidence Interval: 1.35, 2.01, p