Leukocyte telomere length and physical ability among Danish twins age 70+.
Leukocyte telomere length and physical ability among Danish twins age 70+.
复制标题
DOI：
10.1016/j.mad.2011.10.003
复制
发表时间：
2011-11
影响因子：
5.3
通讯作者：
Christensen K
中科院分区：
文献类型：
--
作者：
Bendix L;Gade MM;Staun PW;Kimura M;Jeune B;Hjelmborg JV;Aviv A;Christensen K
白细胞端粒长度 (LTL) 随着年龄的增长而缩短，可能是人类衰老的生物标志物。我们研究了丹麦老年双胞胎纵向研究中 548 名同性双胞胎的 LTL 与身体能力和认知功能的关系。 LTL 通过末端限制性片段 (TRF) 的 Southern 印迹来测量。使用包含 11 个问题的自我报告量表评估身体能力，而认知功能则通过 MMSE 和对年龄相关衰退敏感的认知综合评分进行评分。随机截距模型揭示了 LTL 与身体能力之间存在显着的正相关关系。身体能力得分每增加一个单位，LTL 就会增加 0.066 kb (p=0.01)，相当于大约三年随年龄变化的 LTL 缩短。匹配的案例-双胞胎设计表明，每对中具有较长LTL的双胞胎组成的组也表现出更好的身体能力（p<0.01）。此外，LTL 的配对内差异与身体能力的配对内差异相关（p<0.01），证实了这种关联。然而，我们发现认知功能与 LTL 之间没有关联。老年人的LTL-身体能力关联进一步支持了LTL是人类身体健康狭义背景下的躯体健康指数这一前提。
Leukocyte telomere length (LTL) shortens with age and is potentially a biomarker of human aging. We examined the relation of LTL with physical ability and cognitive function in 548 same-sex twins from the Longitudinal Study of Aging Danish Twins. LTL was measured by Southern blots of the terminal restriction fragments (TRF). Physical ability was evaluated using a self reported scale of 11 questions, while cognitive function was scored by MMSE and a cognitive composite score sensitive to age-related decline. A random intercept model revealed a positive, significant association between LTL and physical ability. For every unit increase in physical ability score, LTL increased by 0.066 kb (p=0.01), equal to approximately three years of age-dependent LTL shortening. A matched case-co-twin design showed that the group consisting of the twins from each pair with the longer LTL also displayed better physical ability (p<0.01). Moreover, the intra-pair difference in LTL was associated with intra-pair difference in physical ability (p<0.01), confirming the association. However, we found no association between cognitive function and LTL. The LTL-physical ability association in the elderly provides further support to the premise that LTL is an index of somatic fitness in the narrow context of human physical health.