THE EFFECTIVENESS OF INSECTICIDE-IMPREGNATED BED NETS IN REDUCING CASES OF MALARIA INFECTION - A METAANALYSIS OF PUBLISHED RESULTS
THE EFFECTIVENESS OF INSECTICIDE-IMPREGNATED BED NETS IN REDUCING CASES OF MALARIA INFECTION - A METAANALYSIS OF PUBLISHED RESULTS
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DOI：
10.4269/ajtmh.1995.52.377
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发表时间：
1995-05-01
影响因子：
3.3
通讯作者：
SEXTON, JD
中科院分区：
文献类型：
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作者：
CHOI, HW;BREMAN, JG;SEXTON, JD
使用浸有杀虫剂的蚊帐尽量减少人与病媒的接触，可能会降低疟疾的发病率。对已发表的测量感染发生率的实地试验报告进行了荟萃分析，以衡量经杀虫剂处理的蚊帐在预防临床疟疾方面的有效性。对10项田间试验进行了子集分析，以计算研究组间的合并感染发生率比。在比较浸有杀虫剂的蚊帐与未经处理的蚊帐的研究中，获得性疟疾感染的总发病率比为0.757（95%置信区间[CI] = 0.612-0.938），降低了24%。对于比较氯菊酯浸渍蚊帐与不使用蚊帐的对照的研究，汇总发病率比值为0.497（95% CI = 0.417-0.592）（Rothman-Boice异质性统计值分别为17.27 [P = 0.004]和23.55 [P = 0.0003]）。这些数据表明，浸有杀虫剂的蚊帐在预防疟疾方面是有效的，在迄今为止进行的实地试验中，发病率比降低了约50%。
The use of insecticide-impregnated bed nets to minimize human-vector contact may reduce the incidence Consequently, several field trials have evaluated their effectiveness as a malaria prevention strategy. A meta-analysis of published reports of field trials that measured the incidence of infections was performed to provide a measure of the effectiveness of insecticide-treated bed nets in preventing clinical malaria. Subsetted analyses were performed on the 10 field trials to calculate pooled incidence rate ratios of infection among the study groups. For the studies comparing insecticide-impregnated bed nets with untreated bed nets, the summary incidence rate ratio for acquiring malarial infections was 0.757 (95% confidence interval [CI] = 0.612-0.938), representing a reduction of 24%. For the studies comparing permethrin-impregnated bed nets with controls without bed nets, the summary incidence rate ratio was 0.497 (95% CI = 0.417-0.592) (Rothman-Boice heterogeneity statistics = 17.27 [P = 0.004] and 23.55 [P = 0.0003], respectively). These data suggest that insecticide-impregnated bed nets are effective in preventing malaria, decreasing the incidence rate ratio by approximately 50% in field trials performed to date.