Evaluation of a Rapid Anisotropic Model for ECG Simulation.
Evaluation of a Rapid Anisotropic Model for ECG Simulation.
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DOI：
10.3389/fphys.2017.00265
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发表时间：
2017
影响因子：
4
通讯作者：
Krause R
中科院分区：
文献类型：
--
作者：
Pezzuto S;Kal'avský P;Potse M;Prinzen FW;Auricchio A;Krause R
最先进的心脏电生理模型只能在高性能计算架构上解决，这些模型能够提供生理驱动的激活图和心电图（ECGs）。这使得在临床实践中采用这种模型几乎是不可能的。心电图成像工具通常依赖于简化的模型，但这些模型在正向问题中忽略了组织的各向异性电导率。此外，他们的结果往往局限于心脏-躯干界面。我们提出了一个充分考虑各向异性组织电导率的正演模型，并在几秒钟内产生标准的12导联心电图。激活序列用三维心肌模型近似，心电图用导联场法计算。这两个求解器都在图形处理单元上实现，并进行了大规模并行化。研究了该方法的数值收敛性和可扩展性。我们还将该方法与双域模型在心电图和激活图方面进行了比较，使用了简化的生理驱动几何结构和6个患者特异性解剖结构。所提出的方法在几秒钟内就能很好地逼近激活图和用双域模型计算的脑电图。这两个解算器都可以很好地扩展到高端硬件。这些方法适用于ECG成像方法，并可能很快变得足够快，可用于交互式仿真工具。
State-of-the-art cardiac electrophysiology models that are able to deliver physiologically motivated activation maps and electrocardiograms (ECGs) can only be solved on high-performance computing architectures. This makes it nearly impossible to adopt such models in clinical practice. ECG imaging tools typically rely on simplified models, but these neglect the anisotropic electric conductivity of the tissue in the forward problem. Moreover, their results are often confined to the heart-torso interface. We propose a forward model that fully accounts for the anisotropic tissue conductivity and produces the standard 12-lead ECG in a few seconds. The activation sequence is approximated with an eikonal model in the 3d myocardium, while the ECG is computed with the lead-field approach. Both solvers were implemented on graphics processing units and massively parallelized. We studied the numerical convergence and scalability of the approach. We also compared the method to the bidomain model in terms of ECGs and activation maps, using a simplified but physiologically motivated geometry and 6 patient-specific anatomies. The proposed methods provided a good approximation of activation maps and ECGs computed with a bidomain model, in only a few seconds. Both solvers scaled very well to high-end hardware. These methods are suitable for use in ECG imaging methods, and may soon become fast enough for use in interactive simulation tools.