ASSOCIATION OF SEPSIS WITH AN IMMUNOSUPPRESSIVE POLYPEPTIDE IN SERUM OF BURN PATIENTS
ASSOCIATION OF SEPSIS WITH AN IMMUNOSUPPRESSIVE POLYPEPTIDE IN SERUM OF BURN PATIENTS
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DOI：
10.1097/00000658-197808000-00014
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发表时间：
1978-01-01
影响因子：
9
通讯作者：
CONSTANTIAN, MB
中科院分区：
文献类型：
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作者：
CONSTANTIAN, MB
对 51 名烧伤患者的血清样本 (190) 进行了免疫抑制活性测试，这可能解释了热损伤后宿主免疫能力下降的原因。这些患者的血清中，有一定比例的患者存在差异，但其血清抑制了正常人外周血淋巴细胞对植物血凝素的反应。免疫抑制活性的发生与损伤的严重程度平行。 10 名严重烧伤患者（严重指数 > 40）中有 10 名出现抑制血清，但 30 名指数为 10-39.9 的患者中只有 20 名，11 名指数为 0-9.9 的患者中只有 3 名出现抑制血清。这些组之间的差异显着 (P < .05)。在所有 19 名脓毒症患者中，免疫抑制血清活性在脓毒症发作之前或同时出现。与对淋巴细胞的作用相反，烧伤血清刺激成纤维细胞增殖。免疫抑制活性与血清皮质醇水平、输血、蛋白质热量营养不良或麻醉无关。抑制血清没有细胞毒性。大多数活性血清因子包含在低分子量（< 10,000 道尔顿）多肽亚组分中。
Serum samples (190) from 51 burned patients were tested for immunosuppressive activity which might explain decreased host immune competence following thermal injury. The serum from a variable but significant percentage of these patients suppressed the response of normal human peripheral blood lymphocytes to phytohemagglutinin. The occurrence of immunosuppressive activity paralleled the severity of the injury. Ten of 10 severely burned patients (severity index > 40), but only 20 of 30 patients with index 10-39.9, and 3 of 11 patients with index 0-9.9 developed suppressive serum. Differences between these groups were significant (P < .05). In all 19 patients who became septic, immunosuppressive serum activity immediately preceded or coincided with the septic episode. In contrast to the effect on lymphocytes, burn sera stimulated fibroblast proliferation. Immunosuppressive activity did not correlate with serum cortisol levels, blood transfusion, protein-calorie malnutrition or anesthesia. Suppressive sera were not cytotoxic. A majority of the active serum factor(s) was contained in a low MW (< 10,000 daltons) polypeptide subfraction.