Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia.
Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia.
复制标题
血管活性肠肽对血管传导的影响不受麻醉的影响。
DOI：
10.1152/ajpregu.1988.255.6.r968
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Hedge,GA
中科院分区：
文献类型：
--
作者：
Bouder,TG;Huffman,LJ;Hedge,GA
在氯胺酮和戊巴比妥(KET/PB)麻醉的大鼠中，血管活性肠肽(VIP)增加了唾液腺、胰腺和甲状腺的血管传导性(VC)，而在许多其他器官中没有观察到Vc的变化。由于麻醉可能改变生理系统的反应性，我们比较了VIP对清醒和麻醉大鼠器官VC的影响。以KET/PB、异氟醚或肌动蛋白诱导麻醉后30min，观察慢性插管大鼠清醒状态和麻醉诱导后30min的变化。采用放射性微球(MS)技术的参考样品版本，使用两次MS注射(141Ce-MS/85Sr-MS)测量血流量。监测平均动脉压并用于计算VC。清醒大鼠和麻醉大鼠在基础状态下器官VCs相似。VIP输注引起全身低血压和唾液腺、胰腺和甲状腺内VCs的增加，这些反应基本上不受麻醉的影响。这些结果表明，使用的麻醉剂不会改变基础VC或血管系统对外源性VIP的反应性。
In rats anesthetized with ketamine and pentobarbital (KET/PB), vasoactive intestinal peptide (VIP) increases vascular conductance (VC) in the salivary gland, pancreas, and thyroid gland, whereas no changes in VC are observed in a number of other organs. Because anesthesia may alter the responsiveness of physiological systems, we compared the effects of VIP on organ VC in conscious or anesthetized rats. Chronically catheterized rats were studied in the conscious state or 30 min after induction of anesthesia with KET/PB, isoflurane, or Inactin. Blood flows were measured by the reference sample version of the radioactive microsphere (MS) technique using two MS injections (141Ce-MS/85Sr-MS). Mean arterial blood pressure was monitored and used in the calculation of VC. Organ VCs were similar under basal conditions in conscious and anesthetized rats. VIP infusion caused systemic hypotension and increased VCs in the salivary gland, pancreas, and thyroid gland, and these responses were largely unaffected by anesthesia. These results indicate that the anesthetics used do not alter basal VC or the responsiveness of the vasculature to exogenous VIP.