Subcutaneous and skeletal muscle vascular responses in human limbs to lower body negative pressure.
Subcutaneous and skeletal muscle vascular responses in human limbs to lower body negative pressure.
复制标题
人体四肢皮下和骨骼肌血管对较低身体负压的反应。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
O. Amtorp
中科院分区：
文献类型：
--
作者：
T. N. Jacobsen;H. Nielsen;E. Kassis;O. Amtorp
人体心肺压力感受器卸荷可明显增加前臂和小腿骨骼肌的交感放电，但血流研究揭示了四肢血管舒缩反应的差异性，而不是均匀性。本研究的目的是解决直立压力对前臂和小腿血管调节的不同影响的问题，并通过确定四肢不同血管床的血管反应的变化来扩展先前的研究。采用局部[133氙]冲洗法记录皮下组织和骨骼肌的血流量。在下体负压为-10 mmHg时，对11名健康年轻男性的前臂和小腿进行同时记录。在下体负压期间，心率、动脉平均压和脉压没有变化。前臂血流量显著下降，皮下组织血流量下降16 +/- 2%（平均+/- SEM），骨骼肌血流量下降16 +/- 1%。犊牛下体负压导致皮下组织和骨骼肌血流速率分别显著降低17% /- 3%和30% /- 2%。小腿骨骼肌的血管收缩在两条腿上持续出现，当研究一条腿暴露在下体负压下，另一条腿暴露在下体负压室外时，每条小腿的血管收缩程度大致相同。这些结果表明，在心肺传入神经卸除过程中，反射性交感神经激活作为一种重要的直立应激自主调节，伴随着人体四肢皮下和骨骼肌血管床的均匀收缩。
Cardiopulmonary baroreceptor unloading in humans comparably increases sympathetic discharge to skeletal muscle in the forearm and calf, but blood flow studies have disclosed differential rather than uniform vasomotor responses in the extremities. The aim of the present study was to address the issue of differential effects of orthostatic stress on forearm and calf vascular adjustment and to extend previous studies by determining changes in vascular responses separately in various vascular beds of the limbs. The local [133Xenon] washout method was used for recording blood flow rates in subcutaneous tissue and skeletal muscle. Simultaneous recordings from the forearm and calf were performed in 11 healthy young males during lower body negative pressure at -10 mmHg. Heart rate, arterial mean and pulse pressures did not change during lower body negative pressure. In the forearm blood flow rates decreased significantly, in subcutaneous tissue by 16 +/- 2% (mean +/- SEM) and in skeletal muscle by 16 +/- 1%. In the calf lower body negative pressure induced a significant decrease in blood flow rates of 17 +/- 3% in subcutaneous tissue and of 30 +/- 2% in skeletal muscle. This vasoconstriction in calf skeletal muscle was consistently disclosed in both legs and was about the same magnitude in each calf when studied with the one leg exposed to lower body negative pressure and the other outside the lower body negative pressure chamber. These findings suggest that during unloading of cardiopulmonary afferents, reflex sympathetic activation as an important autonomic adjustment to orthostatic stress is accompanied by uniform vasoconstriction in subcutaneous and skeletal muscle vascular beds of human limbs.
影响因子：
3.3
作者：
R. Rea;B. Wallin
通讯作者：
R. Rea;B. Wallin
下半身负压对人类腿部肌肉交感神经放电的影响。
DOI：
10.1152/jappl.1987.63.6.2558
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
Victor,RG;LeimbachJr,WN
通讯作者：
LeimbachJr,WN