STRUCTURAL DIFFERENCES OF HEPARAN SULFATES ACCORDING TO THE TISSUE AND SPECIES OF ORIGIN
STRUCTURAL DIFFERENCES OF HEPARAN SULFATES ACCORDING TO THE TISSUE AND SPECIES OF ORIGIN
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DOI：
10.1016/0006-291x(83)91379-7
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
STRAUS, AH
中科院分区：
文献类型：
--
作者：
DIETRICH, CP;NADER, HB;STRAUS, AH
本文报道了从不同哺乳动物组织[胰腺、胸腺、脑、肺、肝、肾、血小板]和种属[牛、兔、豚鼠、狗、人]中分离得到的13种硫酸乙酰肝素的一些结构特征。通过来自肝素黄杆菌的肝素酶I和II的联合作用，由这些化合物形成两种N-乙酰化二糖，其中一种是O-硫酸化二糖，另一种是2种N-硫酸化二糖，其中一种是6-硫酸化二糖。4个二糖单元的相对比例在13种硫酸乙酰肝素中变化相当显著，表明这些聚合物的结构具有组织和种属特异性。基于每一个二糖的出现频率，计算出1036种硫酸乙酰肝素，理论上可以找到这些聚阴离子在细胞-细胞识别中的可能作用。
Some structural features of 13 heparan sulfates isolated from different mammalian tissues [pancreas, thymus, brain, lung, liver, kidney, platelets] and species [beef, rabbit, guinea pig, dog, human] are reported. Two N-acetylated disaccharides, one of them O-sulfated and 2 N-sulfated disaccharides, one of them 6-sulfated are formed from these compounds by the combined action of heparitinases I and II from Flavobacterium heparinum. The relative proportions of the 4 disaccharide units vary quite significantly among the 13 heparan sulfates indicating that the structure of these polymers are tissue and species specific. Based on the frequency of appearance of each one of the disaccharides it was calculated that 1036 types of heparan sulfates might theoretically be found. The possible role of these polyanions in cell-cell recognition is discussed in view of the present findings.