Precision of volumetric assessment of proximal femur microarchitecture from high-resolution 3T MRI.
Precision of volumetric assessment of proximal femur microarchitecture from high-resolution 3T MRI.
复制标题
通过高分辨率 3T MRI 对近端股骨微结构进行体积评估的精度。
DOI：
10.1007/s11548-014-1009-9
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发表时间：
2015
影响因子：
3
通讯作者：
Chang,Gregory
中科院分区：
文献类型：
--
作者：
Hotca,Alexandra;Ravichandra,Shreyas;Mikheev,Artem;Rusinek,Henry;Chang,Gregory
目的评价采用非均匀性校正的高分辨率3T MRI股骨近端骨微结构测量骨体积和骨体积分数的精度。方法本研究符合HIPAA标准，经机构审查委员会批准，共有6名志愿者（平均年龄）参与，并获得了书面知情同意。所有志愿者在三个时间点接受了3T FLASH MRI髋关节扫描：基线，同一天的第二次扫描（扫描内），一周后的第三次扫描（扫描间）。使用内部开发的软件FireVoxel计算股骨图像的分割和股骨近端总体积（）、骨体积（）和骨体积分数（BVF）的值。对图像进行了两种非均匀性校正（N3和BiCal）。使用绝对百分比误差（APE）计算精度值。统计分析采用单样本单侧检验观察精密度的一致性，采用成对检验比较各种方法和扫描结果。结果扫描内和扫描间骨体积测量值无显著差异。当使用非均匀性校正并在小转子水平均匀评估所有受试者时，精度值整体提高，特别是在测量骨体积时显着（）。N3或bic与CLT联合使用的值具有显著一致的APE值小于2.5%，而BVF值均一致且显著低于2.5% APE。结论高分辨率三维MRI测量的精度与双能x线吸收仪相当。通过在小粗隆处裁剪或使用非均匀性校正来对分析技术进行额外的校正有助于提高精度。这些MRI扫描的高精度值为股骨近端MRI作为骨质疏松症诊断和治疗的有前途的工具提供了证据。
PurposeTo evaluate the precision of measures of bone volume and bone volume fraction derived from high-resolution 3T MRI of proximal femur bone microarchitecture using non-uniformity correction.MethodsThis HIPAA compliant, institutional review board approved study was conducted on six volunteers (mean ageyears), and written informed consent was obtained. All volunteers underwent a 3T FLASH MRI hip scan at three time points: baseline, second scan same day (intra-scans), and third scan one week later (inter-scans). Segmentation of femur images and values for total proximal femur volume (), bone volume (), and bone volume fraction (BVF) were calculated using in-house developed software, FireVoxel. Two types of non-uniformity corrections were applied to images (N3 and BiCal). Precision values were calculated using absolute percent error (APE). Statistical analysis was carried out using one-sample one-sidedttest to observe the consistency of the precision and pairedttest to compare between the various methods and scans.ResultsNo significant differences in bone volume measurements were observed for intra- and inter-scans. When using non-uniformity correction and assessing all subjects uniformly at the level of the lesser trochanter, precision values overall improved, especially significantly () when measuring bone volume,.values using the combination of N3 or BiCal with CLT had a significant consistent APE values of less than 2.5 %, while BVF values were all consistently and significantly lower than 2.5 % APE.ConclusionOur results demonstrate the precision of high-resolution 3D MRI measures were comparable to that of dual-energy X-ray absorptiometry. Additional corrections to the analysis technique by cropping at the lesser trochanter or using non-uniformity corrections helped to improve precision. The high precision values from these MRI scans provide evidence for MRI of the proximal femur as a promising tool for osteoporosis diagnosis and treatment.