Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study
Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study
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DOI：
10.2337/dc19-2367
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发表时间：
2020-05-01
期刊：
影响因子：
16.2
通讯作者：
Stehouwer, Coen D. A.
中科院分区：
文献类型：
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作者：
Coopmans, Charlotte;Zhou, Tan Lai;Stehouwer, Coen D. A.
目的低心率变异性（HRV）是心脏自主神经功能障碍的标志物，是2型糖尿病的一个已知特征，但尚不完全清楚这是否也适用于糖尿病前期或整个血糖谱。因此，我们调查了糖尿病前期、2型糖尿病、心率变异性和心率变异性之间的关系。基于人群的马斯特里赫特研究中的研究设计和方法（n = 2，107;平均值+/- SD年龄59 +/- 8岁; 52%男性;正常葡萄糖代谢[n = 1，226]、糖尿病前期[n = 331]和2型糖尿病[n = 550，过采样]），我们在时域和频域中测定了24小时心电图衍生的HRV（分别基于七个和六个变量的个体z分数）。我们使用线性回归，调整了年龄、性别和主要心血管危险因素。结果：调整后，与正常糖代谢组相比，糖尿病前期和2型糖尿病患者的时域和频域HRV均较低（时域标准化β [95%CI]分别为：-0.15 [-0.27; -0.03]和-0.34 [-0.46; -0.22]，P趋势
OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. RESEARCH DESIGN AND METHODS In the population-based Maastricht Study (n = 2,107; mean +/- SD age 59 +/- 8 years; 52% men; normal glucose metabolism [n = 1,226], prediabetes [n = 331], and type 2 diabetes [n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z-scores, based upon seven and six variables, respectively). We used linear regression with adjustments for age, sex, and major cardiovascular risk factors. RESULTS After adjustments, both time and frequency domain HRV were lower in prediabetes and type 2 diabetes as compared with normal glucose metabolism (standardized beta [95% CI] for time domain: -0.15 [-0.27; -0.03] and -0.34 [-0.46; -0.22], respectively, P for trend