Size-Controlled Synthesis of Porphyrinic Metal-Organic Framework and Functionalization for Targeted Photodynamic Therapy
Size-Controlled Synthesis of Porphyrinic Metal-Organic Framework and Functionalization for Targeted Photodynamic Therapy
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DOI：
10.1021/jacs.6b00007
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发表时间：
2016-03-16
影响因子：
15
通讯作者：
Zhou, Hong-Cai
中科院分区：
文献类型：
--
作者：
Park, Jihye;Jiang, Qin;Zhou, Hong-Cai
了解纳米材料用于靶向癌症治疗非常重要，因为纳米材料的物理参数已被证明是可以促进细胞反应的强有力的决定因素。然而，尽管在这些研究中使用了各种纳米材料，但很少有平台可以在分子水平上极大地调节纳米颗粒的核心。在这里，我们展示了基于Zr（IV）的卟啉金属有机框架（MOP）纳米颗粒的靶向光动力疗法（PDT）。通过自下而上的方法，MOF纳米颗粒的大小在广泛的范围内精确地调整，具有设计的功能基序，基于选择MOF的构建块。特别地，卟啉连接体的分子性质在MOF纳米颗粒中得以保持，而不管它们的尺寸如何。因此，尺寸依赖性细胞摄取和随后的PDT允许筛选用于PDT的MOF纳米颗粒的最佳尺寸，而光敏剂的MOF纳米颗粒制剂显示出比其小分子更好的PDT功效。此外，MOF中的Zr-6簇通过合成后修饰实现了主动靶向模式，从而进一步增强了PDT功效。连同我们发现的尺寸可控性，覆盖了广泛的纳米制度，我们设想，MOFs可以是一个有前途的纳米平台，通过采用先进的小分子系统到可调的框架与空间合成后的修改。
The understanding of nanomaterials for targeted cancer therapy is of great importance as physical parameters of nanomaterials have been shown to be strong determinants that can promote cellular responses. However, there have been rare platforms that can vastly tune the core of nanoparticles at a molecular level despite various nanomaterials employed in such studies. Here we show targeted photodynamic therapy (PDT) with Zr(IV)-based porphyrinic metal organic framework (MOP) nano particles. Through a bottom-up approach, the size of MOF nanoparticles was precisely tuned in a broad range with a designed functional motif, built upon selection of building blocks of the MOF. In particular, molecular properties of the porphyrinic linker are maintained in the MOF nanoparticles regardless of their sizes. Therefore, size-dependent cellular uptake and ensuing PDT allowed for screening of the optimal size of MOF nanoparticles for PDT while MOF nanoparticle formulation of the photosensitizer showed better PDT efficacy than that of its small molecule. Additionally, Zr-6 clusters in the MOF enabled an active targeting modality through postsynthetic modification, giving even more enhanced PDT efficacy. Together with our finding of size controllability covering a broad range in the nano regime, we envision that MOFs can be a promising nanoplatform by adopting advanced small molecule systems into the tunable framework with room for postsynthetic modification.