Synergism between inflammatory mediators in vivo. Induction of airway hyperresponsiveness to C3a in the guinea pig.
Synergism between inflammatory mediators in vivo. Induction of airway hyperresponsiveness to C3a in the guinea pig.
复制标题
体内炎症介质之间的协同作用。
DOI：
10.1164/ajrccm/137.3.636
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Stimler-Gerard,NP
中科院分区：
文献类型：
--
作者：
Watson,JW;Drazen,JM;Stimler-Gerard,NP
The complement anaphylatoxin C3a causes acute bronchoconstrlction after intravenous infusion in guinea pigs. At doses of 6 to 600 Ilg/kg, the peptide causes significant and dosedependent Increases In resistance (RL) and decreases in dynamic compliance (Cdyn). Inhibition of serum carboxypeptidase N, the enzyme thought to be responsible tor control of C3a activity in blood, by pretreating animals with DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
