Abnormal brain oscillations persist after recovery from bipolar depression
Abnormal brain oscillations persist after recovery from bipolar depression
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DOI：
10.1016/j.eurpsy.2016.10.005
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发表时间：
2017-03-01
影响因子：
7.8
通讯作者：
Benedetti, F.
中科院分区：
文献类型：
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作者：
Canali, P.;Casarotto, S.;Benedetti, F.
当健康受试者受到直接干扰时，前运动皮层区域产生β范围（20-40 Hz）的电振荡。在精神分裂症、重性抑郁症和双相情感障碍（BD）中，这些振荡在幅度和频率方面明显减少。然而，目前仍不清楚这些异常是否可以随着时间的推移而调节，或者在治疗后是否仍然可以观察到。在这里，我们采用经颅磁刺激（TMS）结合脑电图评估前/后的抗抑郁治疗（睡眠剥夺和光疗法），相对于9名健康对照组的18例BD患者的额叶振荡活动。为了检测主频率，事件相关频谱扰动（ERSP）计算每个TMS/EEG会议在所有参与者，使用小波分解。皮质回路振荡的自然频率被计算为在300 ms刺激后时间间隔内具有最大功率的频率值。抑郁症的严重程度显着降低治疗后，12例患者达到反应和9例患者达到缓解。TMS/EEG在健康对照中导致β/γ频带响应（2150 Hz）的显著激活。在患者中，运动前EEG对TMS的反应的主要频率在治疗前后没有显著变化，并且总是显著低于对照组（11-27 Hz），并且在达到缓解的患者和对治疗无反应的患者中具有可比性。这些结果表明，自然频率的降低是BD的一个特征标记，与患者的临床状态无关。目前的研究结果揭示了严重精神疾病的神经生物学基础，并表明TMS/EEG是开发精神病学生物标志物的独特工具。(C)2016 Elsevier Masson SAS。All rights reserved.
When directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20-40 Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after treatment. Here, we employed transcranial magnetic stimulation (TMS) combined with EEG to assess the frontal oscillatory activity in eighteen BD patients before/after antidepressant treatments (sleep deprivation and light therapy), relative to nine healthy controls. In order to detect dominant frequencies, event related spectral perturbations (ERSP) were computed for each TMS/EEG session in all participants, using wavelet decomposition. The natural frequency at which the cortical circuit oscillates was calculated as the frequency value with the largest power across 300 ms post-stimulus time interval. Severity of depression markedly decreased after treatment with 12 patients achieving response and nine patients achieving remission. TMS/EEG resulted in a significant activation of the beta/gamma band response (2150 Hz) in healthy controls. In patients, the main frequencies of premotor EEG responses to TMS did not significantly change before/after treatment and were always significantly lower than those of controls (11-27 Hz) and comparable in patients achieving remission and in those not responding to treatment. These results suggest that the reduction of natural frequencies is a trait marker of BD, independent from the clinical status of the patients. The present findings shed light on the neurobiological underpinning of severe psychiatric disorders and demonstrate that TMS/EEG represents a unique tool to develop biomarkers in psychiatry. (C) 2016 Elsevier Masson SAS. All rights reserved.