Growth Hormone and Premature Ageing
Growth Hormone and Premature Ageing
复制标题
生长激素与过早衰老
作者：
J. Shire
经常有人提出免疫系统可能与衰老有关1-4 Fabris等人声称，这种免疫缺陷是由于生长激素(GH)对淋巴系统的刺激不足造成的。他们将遗传性垂体性侏儒症(斯内尔氏矮小突变纯合子，dw)的小鼠与来自同一种群的正常小鼠进行了比较。侏儒的寿命只有3~5.5个月(平均4.5个月)，而正常同胞的平均寿命为20个月。突变体的过早死亡被认为是过早衰老的迹象。矮小鼠在2到3个月大时出现的毛发脱落和灰白、皮肤萎缩和双眼白内障也被视为衰老的迹象，因为这些变化只发生在正常小鼠生命的最后几个月。一只5个月大的侏儒的几个组织，包括胸腺，对~3H-胸腺嘧啶核苷的摄取低于17个月大的正常小鼠的相应组织。1个月大的矮小和正常小鼠的摄取量都更大。
IT has often been suggested that the immune system may be involved in ageing1–4 Fabris et al.5 claim that such immune deficiencies are caused by inadequate stimulation of the lymphoid system by growth hormone (GH). They compared mice with inherited pituitary dwarfism (homozygotes for Snell's dwarf mutation, dw) with normal mice from the same stock. The life span of the dwarfs was only 3 to 5.5 months (mean 4.5 months) although the mean life span of their normal sibs was 20 months. The early death of the mutants was taken as a sign of premature ageing. The loss and greying of the hair, cutaneous atrophy, and bilateral cataracts which occurred in the dwarf mice from the age of 2 to 3 months were also taken as signs of ageing, as such changes only occurred in normal littermates during their last few months of life. The uptake of 3H-thymidine by several tissues, including the thymus, of a 5-month-old dwarf was less than by the corresponding tissues of a 17-month-old normal mouse. The uptakes were greater in both dwarf and normal mice aged 1 month.