Centriole assembly at a glance
Centriole assembly at a glance
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DOI：
10.1242/jcs.228833
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发表时间：
2019-02-01
影响因子：
4
通讯作者：
Hatzopoulos, Georgios N.
中科院分区：
文献类型：
--
作者：
Gonczy, Pierre;Hatzopoulos, Georgios N.
中心粒细胞器由微管组成，呈现出惊人的9重径向对称性。中心粒在真核生物中发挥着重要的作用，特别是在细胞信号、运动和分裂方面。在这篇《细胞科学概览》的文章和海报中，我们介绍了这种细胞器的细胞生命周期--从组装到消失--重点关注人类的中心粒。这段旅程始于有丝分裂的末期，此时中心粒对分离，新形成的中心粒成熟，开始新的复制周期。接下来，通过聚焦Polo-like kinase4(Plk4)来选择原着丝点出现的单个位置，以及由此产生的纺锤体组装异常蛋白6(SAS-6)组装成一个侧翻元件。随后，我们讨论了外围组件的招募，包括针头结构、MTS和MT连接的A-C连接子。然后介绍了中心粒在招募中心周围物质(PCM)和形成轴丝模板中的作用，接着提到了中心粒形成从头开始或被消除的情况。
The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article and accompanying poster, we cover the cellular life cycle of this organelle - from assembly to disappearance - focusing on human centrioles. The journey begins at the end of mitosis when centriole pairs disengage and the newly formed centrioles mature to begin a new duplication cycle. Selection of a single site of procentriole emergence through focusing of polo-like kinase 4 (PLK4) and the resulting assembly of spindle assembly abnormal protein 6 (SAS-6) into a cartwheel element are evoked next. Subsequently, we cover the recruitment of peripheral components that include the pinhead structure, MTs and the MT-connecting A-C linker. The function of centrioles in recruiting pericentriolar material (PCM) and in forming the template of the axoneme are then introduced, followed by a mention of circumstances in which centrioles form de novo or are eliminated.