ULTRASONIC TISSUE CHARACTERIZATION OF HUMAN HYPERTROPHIED HEARTS INVIVO WITH CARDIAC CYCLE-DEPENDENT VARIATION IN INTEGRATED BACKSCATTER
ULTRASONIC TISSUE CHARACTERIZATION OF HUMAN HYPERTROPHIED HEARTS INVIVO WITH CARDIAC CYCLE-DEPENDENT VARIATION IN INTEGRATED BACKSCATTER
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DOI：
10.1161/01.cir.80.4.925
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发表时间：
1989-10-01
期刊：
影响因子：
37.8
通讯作者：
POPP, RL
中科院分区：
文献类型：
--
作者：
MASUYAMA, T;STGOAR, FG;POPP, RL
超声背向散射积分（IB）是一种无创性的心肌声学特性测量方法。先前的实验研究已经表明，心肌声学特性的改变反映在心动周期期间IB的变化幅度。在我们的研究中，使用定量IB成像系统对12例无并发症的压力超负荷性肥厚患者和13例肥厚性心肌病患者的IB的心动周期依赖性变化进行了无创性测量。16名正常人作为对照。后壁IB的心动周期依赖性变化幅度为6.0 ± 0.01。0.9正常受试者为5.7 . ±. dB。0.8无并发症的压力超负荷性肥大患者的平均舒张压为6.7dB，2.1肥厚型心肌病患者的dB。这些组之间没有显著差异。相比之下，在无并发症的压力超负荷性肥大患者中，间隔IB的心动周期依赖性变化幅度显著较小（2.8 ± 0.05）。1.3 dB）和肥厚型心肌病患者（3.1 . ±. 2.3 dB）比正常受试者（4.9 . ±. 1.0 dB）。随着室壁厚度指数的增加，IB的心动周期依赖性变化幅度较小（r=-0.53，p < 0.01，所有数据n = 82）。该IB测量也与心肌的收缩期前增厚相关（r= 0.67，p < 0.01，n = 82）。因此，在肥厚心脏中观察到IB的心动周期依赖性变化幅度的改变，并显示出明显的区域心肌差异。
Integrated ultrasonic backscatter (IB) is a noninvasive measure of the acoustic properties of myocardium. Previous experimental studies have indicated that altered acoustic properties of the myocardium are reflected by the magnitude of variation of IB during the cardiac cycle. In our study, cardiac cycle-dependent variation of IB was noninvasively measured using a quantitative IB imaging system in 12 patients with uncomplicated pressure-overload hypertrophy and 13 patients with hypertrophic cardiomyopathy. Sixteen normal subjects served as a control. The magnitude of cardiac cycle-dependent variation of IB for the posterior wall was 6.0 .+-. 0.9 dB in normal subjects, 5.7 .+-. 0.8 dB in the patients with uncomplicated pressure-overload hypertrophy, and 6.7 .+-. 2.1 dB in the patients with hypertrophic cardiomyopathy. There were no significant differences among any of these groups. In contrast, the magnitude of cardiac cycle-dependent variation of IB for the septum was significantly smaller in the patients with uncomplicated pressure-overload hypertrophy (2.8 .+-. 1.3 dB) and in the patients with hypertrophic cardiomyopathy (3.1 .+-. 2.3 dB) than in normal subjects (4.9 .+-. 1.0 dB). The magnitude of cardiac cycle-dependent variation of IB was smaller as the wall-thickness index increased (r= -0.53, p < 0.01, n = 82 for all data). This IB measure also correlated with percent-systolic thickening of the myocardium (r= 0.67, p < 0.01, n = 82). Thus, alteration in the magnitude of cardiac cycle-dependent variation of IB was observed in hypertrophic hearts and showed apparent regional myocardial differences.