The human papillomavirus infection in men study: human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States.
The human papillomavirus infection in men study: human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States.
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DOI：
10.1158/1055-9965.epi-08-0151
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Quiterio M
中科院分区：
文献类型：
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作者：
Giuliano AR;Lazcano-Ponce E;Villa LL;Flores R;Salmeron J;Lee JH;Papenfuss MR;Abrahamsen M;Jolles E;Nielson CM;Baggio ML;Silva R;Quiterio M
男性性行为影响宫颈发育不良和侵袭性宫颈癌的发病率，以及男性人乳头瘤病毒（HPV）感染和疾病的发病率。不幸的是，关于男性HPV类型按年龄和国家分布的情况知之甚少。在25.7%的研究参与者中检测到多种HPV类型。HPV患病率在巴西（72.3%）高于美国（61.3%）和墨西哥（61.9%）。HPV16（6.5%）、HPV51（5.3%）和HPV59（5.3%）是最常见的致瘤感染，HPV84（7.7%）、HPV62（7.3%）和HPV6（6.6%）是最常见的非致瘤感染。总体HPV患病率与年龄无关。然而，当考虑特定类型的HPV、非致瘤性和未分类的HPV感染时，观察到与年龄的显著关联。需要对来自多个国家的广泛年龄范围的男性的HPV类型分布进行研究，以填补国际上关于我们对男性HPV感染的知识的信息差距。
Male sexual behavior influences the rates of cervical dysplasia and invasive cervical cancer, as well as male human papillomavirus (HPV) infection and disease. Unfortunately, little is known regarding male HPV type distribution by age and across countries. In samples combined from the coronal sulcus, glans penis, shaft, and scrotum of 1,160 men from Brazil, Mexico, and the United States, overall HPV prevalence was 65.2%, with 12.0% oncogenic types only, 20.7% nononcogenic types only, 17.8% both oncogenic and nononcogenic, and 14.7% unclassified infections. Multiple HPV types were detected in 25.7% of study participants. HPV prevalence was higher in Brazil (72.3%) than in the United States (61.3%) and Mexico (61.9%). HPV16 (6.5%), HPV51 (5.3%), and HPV59 (5.3%) were the most commonly detected oncogenic infections, and HPV84 (7.7%), HPV62 (7.3%), and HPV6 (6.6%) were the most commonly detected nononcogenic infections. Overall HPV prevalence was not associated with age. However, significant associations with age were observed when specific categories of HPV, nononcogenic, and unclassified HPV infections were considered. Studies of HPV type distribution among a broad age range of men from multiple countries is needed to fill the information gap internationally with respect to our knowledge of HPV infection in men.