Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysis
Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysis
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DOI：
10.1097/cej.0b013e3283481d89
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发表时间：
2012-01-01
影响因子：
2.4
通讯作者：
Hu, Xiangui
中科院分区：
文献类型：
--
作者：
Jing, Wei;Jin, Gang;Hu, Xiangui
据报道，糖尿病（DM）与几种癌症的风险增加有关。然而，其与胆管癌（CC）（包括肝内胆管癌（ICC）和肝外胆管癌（ECC））的关系尚不清楚。我们进行了一项荟萃分析，以评估糖尿病与CC（包括ICC和ECC）风险之间的关系。我们通过文献检索Medline（从1966年1月1日起）和Embase（从1974年1月1日起），至2010年11月30日，并通过检索相关文章的参考文献列表来识别研究。使用随机效应模型计算总结相对风险（RR）及其相应的95%置信区间（CI）。本研究共纳入15篇文章（10项病例对照研究和5项队列研究）。关于DM和特定癌症风险的报告数量如下：CC（n = 5）、ECC（n = 9）和ICC（n = 9）。与那些没有糖尿病的人相比，糖尿病患者患CC的风险增加（汇总RR，1.60; 95% CI，1.38-1.87;异质性P = 0.992），ECC（总体RR，1.63; 95% CI，1.29-2.05;异质性P = 0.005）和ICC（总体RR，1.97; 95% CI，1.57-2.46;异质性P = 0.025）。漏斗图显示没有证据表明糖尿病和CC风险（包括ICC和ECC）的发表偏倚。这些发现强烈支持DM与CC（包括ICC和ECC）风险增加之间的正相关。欧洲癌症预防杂志21：24-31（C）2011年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Diabetes mellitus (DM) has been reported to be associated with an increased risk of several types of cancers. However, its relationship with cholangiocarcinoma (CC), which includes intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC), remains unclear. We conducted a meta-analysis to assess the association between diabetes and the risk of CC (including ICC and ECC). We identified studies by a literature search of Medline (from 1 January 1966) and Embase (from 1 January 1974), through 30 November 2010, and by searching the reference lists of pertinent articles. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated with a random-effects model. A total of 15 articles (10 case-control and five cohort studies) were included in this study. The number of reports on DM and risk of specific cancer were as follows: CC (n = 5), ECC (n = 9), and ICC (n = 9). Compared with those without diabetes, individuals with diabetes had an increased risk of CC (summary RRs, 1.60; 95% CI, 1.38-1.87; P = 0.992 for heterogeneity), ECC (summary RRs, 1.63; 95% CIs, 1.29-2.05; P = 0.005 for heterogeneity), and ICC (summary RRs, 1.97; 95% CIs, 1.57-2.46; P = 0.025 for heterogeneity). The funnel plot revealed no evidence for publication bias concerning diabetes and the risk of CC (including ICC and ECC). These findings strongly support the positive link between DM and the increased risk of CC (including ICC and ECC). European Journal of Cancer Prevention 21:24-31 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.